Simulated clustering dynamics of colloidal magnetic nanoparticles

Durhuus, Frederik Laust; Wandall, Lau Halkier; Boisen, Mathias Hoeg; Kure, Mathias; Beleggia, Marco; Frandsen, Cathrine

doi:10.1039/d0nr08561h

Cited by 19 publications

(13 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 37 ] A common strategy is to employ a ligand‐assisted approach through rational design to integrate nanoparticles into smart response materials. [ 38 ] Stimuli‐responsive magnetic nanoparticles, [ 39 ] quantum dots, [ 40 ] metal oxide particles, [ 41 ] and other materials have been widely used as the building blocks of the assembled drug carriers. Accordingly, drugs can be accurately delivered at specific sites by using carrier materials that can self‐assemble and disassemble in response to the environment.…”

Section: Interactions and Responsive Release Mechanismmentioning

confidence: 99%

Response and Regulation of the Microenvironment Based on Hollow Structured Drug Delivery Systems

Zhao

Wei

Xiong

et al. 2023

Adv Funct Materials

View full text Add to dashboard Cite

Hollow structured materials with easily modifiable surfaces and enclosed interior spaces have emerged as the most promising candidates in drug delivery systems (DDS). With various functional components and inspiring cavities for creative reinvention, the response and regulation of the external and internal microenvironment of hollow structures enable their ideal drug delivery capabilities by improving drug aggregation in targeted sites and maintaining plasma concentrations at the optimal therapeutic ranges. This review begins with an in-depth explanation of the interactions and release mechanisms of hollow structure-based DDS, including diffusion, assembly, solvent activation, and chemical control, all of which are of great significance for the design of smart drug carriers. Next, recent advances in external microenvironmentresponsive drug delivery systems are introduced, based on various chemical signals and external field assists. Focusing on the unique view of intra-carrier variability, the strategies for regulating the internal environment are then highlighted, including pH regulation, temperature regulation, and mechanical force regulation. Finally, this review discusses possible challenges and prospects for hollow structure-based, particularly hollow multishelled structures intelligence-responsive drug delivery platforms, providing valuable strategies for the development of the next generation of responsive DDS.

show abstract

Section: Interactions and Responsive Release Mechanismmentioning

confidence: 99%

Response and Regulation of the Microenvironment Based on Hollow Structured Drug Delivery Systems

Zhao

Wei

Xiong

et al. 2023

Adv Funct Materials

View full text Add to dashboard Cite

show abstract

“…The reason lays in the fact that these individual particles behave as tiny permanent magnets. Clearly, such nanoparticles are probably impossible to assemble in a fully controllable way, due to spontaneous dipole interactions among nanoparticles that disturb the externally triggered magnetic assembly process [ 90 ].…”

Section: Natural and Bioinspired Synthetic Approaches To Form Magnetic Nanochainsmentioning

confidence: 99%

Bioinspired Magnetic Nanochains for Medicine

Kralj

Marchesan

2021

Pharmaceutics

View full text Add to dashboard Cite

Superparamagnetic iron oxide nanoparticles (SPIONs) have been widely used for medicine, both in therapy and diagnosis. Their guided assembly into anisotropic structures, such as nanochains, has recently opened new research avenues; for instance, targeted drug delivery. Interestingly, magnetic nanochains do occur in nature, and they are thought to be involved in the navigation and geographic orientation of a variety of animals and bacteria, although many open questions on their formation and functioning remain. In this review, we will analyze what is known about the natural formation of magnetic nanochains, as well as the synthetic protocols to produce them in the laboratory, to conclude with an overview of medical applications and an outlook on future opportunities in this exciting research field.

show abstract

“…However, cluster formation can dramatically change their collective magnetic properties and may consequently cause challenge in controlling the magnetic particles in particular applications, while the information of how they form the clusters in different conditions, such as flow velocity, and efficiency of margination when they form cluster, remains insufficient. There are numerous studies mentioned about the variety of clustering patterns in colloidal suspension [3]. However, the study did not mention the cluster formation in nonequilibrium condition such as fluid flow.…”

Section: Introductionmentioning

confidence: 99%

A simulation study of magnetic nanoparticle clustering in a fluid flow

Kosolpattanadurong,

Sodsri,

Khetubol

et al. 2023

J. Phys.: Conf. Ser.

View full text Add to dashboard Cite

The assembly of magnetic nanoparticles has been promisingly used in biomedical applications. Several computational studies have addressed the study of cluster formation in the colloidal regime. However, these studies did not mention the formation of clusters in nonequilibrium conditions, such as fluid flow. To fill this gap, we develop computational models of magnetohydrodynamic systems to study their behavior within a flow in terms of cluster shape formation. All simulations were performed by Verlet integration through LAMMPS, a molecular dynamics framework. Through simulations, we discover that the fluid flow promotes formation of non-linear clusters, and linear clusters tend to orient toward the direction of the flow. These phenomena are investigated by using the equilibrium of magnetic torque and fluid torque. The analysis shows that the formation of non-linear clusters are mainly assisted by a bias-orientation of the unstable linear clusters, while the bias-orientation is originated from the torque cancellation in the direction of the flow.

show abstract

Simulated clustering dynamics of colloidal magnetic nanoparticles

Abstract: Prediction of magnetic nanoparticle self-assembly and clustering. A Langevin dynamics study with dipole-interactions, van der Waals forces and Brownian motion.

Cited by 19 publications

References 68 publications

Response and Regulation of the Microenvironment Based on Hollow Structured Drug Delivery Systems

Response and Regulation of the Microenvironment Based on Hollow Structured Drug Delivery Systems

Bioinspired Magnetic Nanochains for Medicine

A simulation study of magnetic nanoparticle clustering in a fluid flow

Contact Info

Product

Resources

About