Simulated microgravity accelerates aging in Saccharomyces cerevisiae

Fukuda, Ana Paula Montanari; Camandona, Vittoria de Lima; Francisco, Kelliton José Mendonça; Rios-Anjos, Rafaela Maria; Lago, Claudimir Lúcio do; Ferreira-Junior, Jose Ribamar

doi:10.1016/j.lssr.2020.12.003

Cited by 5 publications

(4 citation statements)

References 66 publications

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“…The growth of yeast in space or in BLSS will obviously present challenges. Whilst yeast cells can grow efficiently in microgravity conditions [ 41 ], it does appear that their lifespan is shortened [ 55 ]. However, targeted deletion of certain genes can restore lifespan.…”

Section: Discussionmentioning

confidence: 99%

An Electro–Microbial Process to Uncouple Food Production from Photosynthesis for Application in Space Exploration

Bell¹,

Paras²,

Mandarakas³

et al. 2022

Life

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Here we propose the concept of an electro–microbial route to uncouple food production from photosynthesis, thereby enabling production of nutritious food in space without the need to grow plant-based crops. In the proposed process, carbon dioxide is fixed into ethanol using either chemical catalysis or microbial carbon fixation, and the ethanol created is used as a carbon source for yeast to synthesize food for human or animal consumption. The process depends upon technologies that can utilize electrical energy to fix carbon into ethanol and uses an optimized strain of the yeast Saccharomyces cerevisiae to produce high-quality, food-grade, single-cell protein using ethanol as the sole carbon source in a minimal medium. Crops performing photosynthesis require months to mature and are challenging to grow under the conditions found in space, whereas the electro–microbial process could generate significant quantities of food on demand with potentially high yields and productivities. In this paper we explore the potential to provide yeast-based protein and other nutrients relevant to human dietary needs using only ethanol, urea, phosphate, and inorganic salts as inputs. It should be noted that as well as having potential to provide nutrition in space, this novel approach to food production has many valuable terrestrial applications too. For example, by enabling food production in climatically challenged environments, the electro–microbial process could potentially turn deserts into food bowls. Similarly, surplus electricity generated from large-scale renewable power sources could be used to supplement the human food chain.

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Section: Discussionmentioning

confidence: 99%

An Electro–Microbial Process to Uncouple Food Production from Photosynthesis for Application in Space Exploration

Bell¹,

Paras²,

Mandarakas³

et al. 2022

Life

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show abstract

“…Several studies both on experimental animal models and astronauts examined the impact of the Space environment on aging and age‐associated changes (Biolo et al, 2003 ; Fukuda et al, 2021 ; Garrett‐Bakelman et al, 2019 ; Honda et al, 2012 ; Le Bourg, 1999 ; Lescale et al, 2015 ; Ma et al, 2015 ; Nwanaji‐Enwerem et al, 2020 ; Otsuka et al, 2022 ; 2019 ; Strollo, 2000 ; Takahashi et al, 2021 ; Vernikos & Schneider, 2010 ; Wang, 1999 ; Wang et al, 2009 ). During spaceflight, astronauts experience numerous disruptions of physiological functions including muscle atrophy (Fitts et al, 2010 ), bone loss (Narici & de Boer, 2011 ), sleep disruption, and behavioural changes (Barger et al, 2014 ), which, to some extent, resemble alterations observed during aging on Earth.…”

Section: Alteration Of Circadian Clock and Spaceflight: An (Anti)agin...mentioning

confidence: 99%

“…In vitro culture of human skeletal muscle myoblasts (which can fusion to multinucleated myotubes/myofibers and eventually differentiate into young and adult muscle fibers) under simulated microgravity resulted in decreased cell proliferation and cytoskeleton enlargement of cells similar to changes observed during normal aging (Takahashi et al, 2021 ). Also in vitro experiments in Yeast fungi, Saccharomyces cerevisiae , seem to point to a correlation between aging‐induced phenotype due to altered gravity conditions, and signs of accelerated aging including oxidative stress and heat shock protein expression under simulated microgravity (Fukuda et al, 2021 ).…”

Section: Alteration Of Circadian Clock and Spaceflight: An (Anti)agin...mentioning

confidence: 99%

Circadian regulation in aging: Implications for spaceflight and life on earth

et al. 2023

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Alterations in the circadian system are characteristic of aging on Earth. With the decline in physiological processes due to aging, several health concerns including vision loss, cardiovascular disorders, cognitive impairments, and muscle mass loss arise in elderly populations. Similar health risks are reported as “red flag” risks among astronauts during and after a long‐term Space exploration journey. However, little is known about the common molecular alterations underlying terrestrial aging and space‐related aging in astronauts, and controversial conclusions have been recently reported. In light of the regulatory role of the circadian clock in the maintenance of human health, we review here the overlapping role of the circadian clock both on aging on Earth and spaceflight with a focus on the four most affected systems: visual, cardiovascular, central nervous, and musculoskeletal systems. In this review, we briefly introduce the regulatory role of the circadian clock in specific cellular processes followed by alterations in those processes due to aging. We next summarize the known molecular alterations associated with spaceflight, highlighting involved clock‐regulated genes in space flown Drosophila, nematodes, small mammals, and astronauts. Finally, we discuss common genes that are altered in terms of their expression due to aging on Earth and spaceflight. Altogether, the data elaborated in this review strengthen our hypothesis regarding the timely need to include circadian dysregulation as an emerging hallmark of aging on Earth and beyond.

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“…Clinostat Reduction in longevity. [21] Saccharomyces cerevisiae Rotary cell culture system Modification of budding. [22] Saccharomyces cerevisiae HARV Modification of budding and clusters formation.…”

Section: Saccharomyces Cerevisiaementioning

confidence: 99%

Simulated Microgravity Created Using a Random Positioning Machine Induces Changes in the Physiology of the Fusarium solani Species Complex

et al. 2022

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Fusarium is a phytopathogenic fungus involved in human pathology and is present in space stations. It is essential to understand the effects of microgravity on the physiology of this fungus to determine the potential risks to the health of crew members and to propose the necessary countermeasures. This study aimed to determine changes in the physiological parameters of the Fusarium solani species complex under simulated microgravity generated using a random positioning machine (RPM) and phenotypic approaches. We observed increased growth, spore production, and germination while biofilm production was reduced under RPM exposure. These in vitro data show the importance of further studying this fungus as it has been repeatedly demonstrated that microgravity weakens the immune system of astronauts.

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Simulated microgravity accelerates aging in Saccharomyces cerevisiae

Cited by 5 publications

References 66 publications

An Electro–Microbial Process to Uncouple Food Production from Photosynthesis for Application in Space Exploration

An Electro–Microbial Process to Uncouple Food Production from Photosynthesis for Application in Space Exploration

Circadian regulation in aging: Implications for spaceflight and life on earth

Simulated Microgravity Created Using a Random Positioning Machine Induces Changes in the Physiology of the Fusarium solani Species Complex

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