Simulated Microgravity Induces Regionally Distinct Neurovascular and Structural Remodeling of Skeletal Muscle and Cutaneous Arteries in the Rat

Тарасова, О.С.; Kalenchuk, V. U.; Боровик, А. С.; Golubinskaya, Veronika; Delp, Michael D.; Виноградова, О. Л.

doi:10.3389/fphys.2020.00675

Cited by 5 publications

(3 citation statements)

References 42 publications

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“…For example, Prisby et al (2015) report that increased vascular resistance seen in HU rodents results from reduced endothelium-dependent vasodilation, as opposed to increased vasoconstriction response. Similarly, Tarasova et al (2020) noted that HU impairs sympathetic vasoconstriction, which is consistent with humans post-spaceflight. As vasoconstriction can be impacted by the presence or absence of the endothelium in an exercise and age-dependent manner, it is also important to note the differences in response that might be seen for in vivo vs. in vitro samples when considering microgravity effects (Ghosh et al, 2015).…”

Section: Vascular Smooth Muscle Cellssupporting

confidence: 67%

The Effects of Simulated and Real Microgravity on Vascular Smooth Muscle Cells

Ludtka,

Allen

2024

Gravitational and Space Research

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As considerations are being made for the limitations and safety of long-term human spaceflight, the vasculature is important given its connection to and impact on numerous organ systems. As a major constituent of blood vessels, vascular smooth muscle cells are of interest due to their influence over vascular tone and function. Additionally, vascular smooth muscle cells are responsive to pressure and flow changes. Therefore, alterations in these parameters under conditions of microgravity can be functionally disruptive. As such, here we review and discuss the existing literature that assesses the effects of microgravity, both actual and simulated, on smooth muscle cells. This includes the various methods for achieving or simulating microgravity, the animal models or cells used, and the various durations of microgravity assessed. We also discuss the various reported findings in the field, which include changes to cell proliferation, gene expression and phenotypic shifts, and renin-angiotensin-aldosterone system (RAAS), nitric oxide synthase (NOS), and Ca2+ signaling. Additionally, we briefly summarize the literature on smooth muscle tissue engineering in microgravity as well as considerations of radiation as another key component of spaceflight to contextualize spaceflight experiments, which by their nature include radiation exposure. Finally, we provide general recommendations based on the existing literature's focus and limitations.

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Section: Vascular Smooth Muscle Cellssupporting

confidence: 67%

The Effects of Simulated and Real Microgravity on Vascular Smooth Muscle Cells

Ludtka,

Allen

2024

Gravitational and Space Research

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“…Remodeling muscle cells (Tarasova et al, 2020) Change of Ca signaling linked to ryanodine receptor subtype 1 expression (Dabertrand et al, 2012).…”

Section: Musclementioning

confidence: 99%

“…The muscular symptomatology is linked to a remodeling of the skeletal muscle (Tarasova et al, 2020) linked to an adaptation of Ca signaling pathways by the regulation of the ryanodine receptor subtype 1 expression (Dabertrand et al, 2012). This perturbation can be preventing by treating cells with thapsigargin that hinders the segregation of calcium ions in the mitochondria and in the sarco/endoplasmic reticula (Calzia et al, 2020).…”

Section: Brainmentioning

confidence: 99%

Spaceflight Induced Disorders: Potential Nutritional Countermeasures

Costa

Ambesi-Impiombato

Beccari

et al. 2021

Front. Bioeng. Biotechnol.

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Space travel is an extreme experience even for the astronaut who has received extensive basic training in various fields, from aeronautics to engineering, from medicine to physics and biology. Microgravity puts a strain on members of space crews, both physically and mentally: short-term or long-term travel in orbit the International Space Station may have serious repercussions on the human body, which may undergo physiological changes affecting almost all organs and systems, particularly at the muscular, cardiovascular and bone compartments. This review aims to highlight recent studies describing damages of human body induced by the space environment for microgravity, and radiation. All novel conditions, to ally unknown to the Darwinian selection strategies on Earth, to which we should add the psychological stress that astronauts suffer due to the inevitable forced cohabitation in claustrophobic environments, the deprivation from their affections and the need to adapt to a new lifestyle with molecular changes due to the confinement. In this context, significant nutritional deficiencies with consequent molecular mechanism changes in the cells that induce to the onset of physiological and cognitive impairment have been considered.

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AOP report: Development of an adverse outcome pathway for deposition of energy leading to abnormal vascular remodeling

Kozbenko,

Adam,

Grybas

et al. 2024

Environ and Mol Mutagen

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Cardiovascular diseases (CVDs) are complex, encompassing many types of heart pathophysiologies and associated etiologies. Radiotherapy studies have shown that fractionated radiation exposure at high doses (3–17 Gy) to the heart increases the incidence of CVD. However, the effects of low doses of radiation on the cardiovascular system or the effects from space travel, where radiation and microgravity are important contributors to damage, are not clearly understood. Herein, the adverse outcome pathway (AOP) framework was applied to develop an AOP to abnormal vascular remodeling from the deposition of energy. Following the creation of a preliminary pathway with the guidance of field experts and authoritative reviews, a scoping review was conducted that informed final key event (KE) selection and evaluation of the Bradford Hill criteria for the KE relationships (KERs). The AOP begins with a molecular initiating event of deposition of energy; ionization events increase oxidative stress, which when persistent concurrently causes the release of pro‐inflammatory mediators, suppresses anti‐inflammatory mechanisms and alters stress response signaling pathways. These KEs alter nitric oxide levels leading to endothelial dysfunction, and subsequent abnormal vascular remodeling (the adverse outcome). The work identifies evidence needed to strengthen understanding of the causal associations for the KERs, emphasizing where there are knowledge gaps and uncertainties in both qualitative and quantitative understanding. The AOP is anticipated to direct future research to better understand the effects of space on the human body and potentially develop countermeasures to better protect future space travelers.

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Simulated Microgravity Induces Regionally Distinct Neurovascular and Structural Remodeling of Skeletal Muscle and Cutaneous Arteries in the Rat

Cited by 5 publications

References 42 publications

The Effects of Simulated and Real Microgravity on Vascular Smooth Muscle Cells

The Effects of Simulated and Real Microgravity on Vascular Smooth Muscle Cells

Spaceflight Induced Disorders: Potential Nutritional Countermeasures

AOP report: Development of an adverse outcome pathway for deposition of energy leading to abnormal vascular remodeling

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