Simulated mobile communication frequencies (3.5 GHz) emitted by a signal generator affects the sleep of Drosophila melanogaster

Wang, Yahong; Zhang, Hongying; Zhang, Ziyan; Sun, Boqun; Tang, Chao; Zhang, Lu; Jiang, Zhihao; Ding, Bo; Liao, Yulin; Cai, Peng

doi:10.1016/j.envpol.2021.117087

Cited by 8 publications

(4 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The sleep duration in Drosophila melanogaster increases following aseptic injury [ 70 ]. Long-term radiofrequency radiation exposure enhances the heat stress response and affects the expression of the circadian clock and neurotransmitter genes, thereby prolonging sleep duration [ 71 ]. SIS in C. elegans can be triggered by conditions of cellular stress, including noxious heat, cold, hyperosmolarity, ultraviolet irradiation, and mechanical injury [ 72 ], and exhibits behavioral quiescence similar to DTS [ 73 ].…”

Section: Tea and Sleepmentioning

confidence: 99%

New Perspectives on Sleep Regulation by Tea: Harmonizing Pathological Sleep and Energy Balance under Stress

Ouyang

Peng

Gong

2022

Foods

View full text Add to dashboard Cite

Sleep, a conservative evolutionary behavior of organisms to adapt to changes in the external environment, is divided into natural sleep, in a healthy state, and sickness sleep, which occurs in stressful environments or during illness. Sickness sleep plays an important role in maintaining energy homeostasis under an injury and promoting physical recovery. Tea, a popular phytochemical-rich beverage, has multiple health benefits, including lowering stress and regulating energy metabolism and natural sleep. However, the role of tea in regulating sickness sleep has received little attention. The mechanism underlying tea regulation of sickness sleep and its association with the maintenance of energy homeostasis in injured organisms remains to be elucidated. This review examines the current research on the effect of tea on sleep regulation, focusing on the function of tea in modulating energy homeostasis through sickness sleep, energy metabolism, and damage repair in model organisms. The potential mechanisms underlying tea in regulating sickness sleep are further suggested. Based on the biohomology of sleep regulation, this review provides novel insights into the role of tea in sleep regulation and a new perspective on the potential role of tea in restoring homeostasis from diseases.

show abstract

Section: Tea and Sleepmentioning

confidence: 99%

New Perspectives on Sleep Regulation by Tea: Harmonizing Pathological Sleep and Energy Balance under Stress

Ouyang

Peng

Gong

2022

Foods

View full text Add to dashboard Cite

show abstract

“…Whether these effects are still measurable using SAR levels complying with the guidelines remains to be determined. Wang et al assessed the impact of short- and long-term exposures using unmodulated 3.5 GHz RF-EMF at three different SAR (2.6, 26, and 260 mW/kg) on Drosophila melanogaster 9 , 10 . These authors showed a moderate but significant impact on insect activity, sleep, and development that was accompanied by a modification in the expression of genes involved in circadian rhythms, thermal stress, oxidative stress, and humoral immunity.…”

Section: Introductionmentioning

confidence: 99%

Effects of 5G-modulated 3.5 GHz radiofrequency field exposures on HSF1, RAS, ERK, and PML activation in live fibroblasts and keratinocytes cells

Joushomme

Orlacchio

Patrignoni

et al. 2023

Sci Rep

View full text Add to dashboard Cite

The potential health risks of exposure to radiofrequency electromagnetic fields from mobile communications technologies have raised societal concerns. Guidelines have been set to protect the population (e.g. non-specific heating above 1 °C under exposure to radiofrequency fields), but questions remain regarding the potential biological effects of non-thermal exposures. With the advent of the fifth generation (5G) of mobile communication, assessing whether exposure to this new signal induces a cellular stress response is one of the mandatory steps on the roadmap for a safe deployment and health risk evaluation. Using the BRET (Bioluminescence Resonance Energy-Transfer) technique, we assessed whether continuous or intermittent (5 min ON/ 10 min OFF) exposure of live human keratinocytes and fibroblasts cells to 5G 3.5 GHz signals at specific absorption rate (SAR) up to 4 W/kg for 24 h impact basal or chemically-induced activity of Heat Shock Factor (HSF), RAt Sarcoma virus (RAS) and Extracellular signal-Regulated Kinases (ERK) kinases, and Promyelocytic Leukemia Protein (PML), that are all molecular pathways involved in environmental cell-stress responses. The main results are (i), a decrease of the HSF1 basal BRET signal when fibroblasts cells were exposed at the lower SARs tested (0.25 and 1 W/kg), but not at the highest one (4 W/kg), and (ii) a slight decrease of As2O3 maximal efficacy to trigger PML SUMOylation when fibroblasts cells, but not keratinocytes, were continuously exposed to the 5G RF-EMF signal. Nevertheless, given the inconsistency of these effects in terms of impacted cell type, effective SAR, exposure mode, and molecular cell stress response, we concluded that our study show no conclusive evidence that molecular effects can arise when skin cells are exposed to the 5G RF-EMF alone or with a chemical stressor.

show abstract

“…In Drosophila melanogaster , 3.5 GHz exposure enhanced the expression of heat shock, oxidative stress, and humoral immunity system genes leading to fly developmental promotion (Wang et al, 2022). In addition, long‐term exposure resulted in alterations of the expression of circadian clock genes resulting in improvement of sleep duration (Wang et al, 2021). Exposure of diabetic and healthy rats brains revealed an increase in appetite, energy metabolism, and oxidative stress (Bektas et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of mitochondrial stress following ultraviolet radiation and 5G radiofrequency field exposure in human skin cells

Patrignoni,

Hurtier,

Orlacchio

et al. 2023

Bioelectromagnetics

View full text Add to dashboard Cite

Whether human cells are impacted by environmental electromagnetic fields (EMF) is still a matter of debate. With the deployment of the fifth generation (5G) of mobile communication technologies, the carrier frequency is increasing and the human skin becomes the main biological target. Here, we evaluated the impact of 5G‐modulated 3.5 GHz radiofrequency (RF) EMF on mitochondrial stress in human fibroblasts and keratinocytes that were exposed for 24 h at specific absorption rate of 0.25, 1, and 4 W/kg. We assessed cell viability, mitochondrial reactive oxygen species (ROS) production, and membrane polarization. Knowing that human skin is the main target of environmental ultraviolet (UV), using the same read‐out, we investigated whether subsequent exposure to 5G signal could alter the capacity of UV‐B to damage skin cells. We found a statistically significant reduction in mitochondrial ROS concentration in fibroblasts exposed to 5G signal at 1 W/kg. On the contrary, the RF exposure slightly but statistically significantly enhanced the effects of UV‐B radiation specifically in keratinocytes at 0.25 and 1 W/kg. No effect was found on mitochondrial membrane potential or apoptosis in any cell types or exposure conditions suggesting that the type and amplitude of the observed effects are very punctual.

show abstract

Simulated mobile communication frequencies (3.5 GHz) emitted by a signal generator affects the sleep of Drosophila melanogaster

Cited by 8 publications

References 36 publications

New Perspectives on Sleep Regulation by Tea: Harmonizing Pathological Sleep and Energy Balance under Stress

New Perspectives on Sleep Regulation by Tea: Harmonizing Pathological Sleep and Energy Balance under Stress

Effects of 5G-modulated 3.5 GHz radiofrequency field exposures on HSF1, RAS, ERK, and PML activation in live fibroblasts and keratinocytes cells

Evaluation of mitochondrial stress following ultraviolet radiation and 5G radiofrequency field exposure in human skin cells

Contact Info

Product

Resources

About