Simulated sleep apnea alters hydrogen sulfide regulation of blood flow and pressure

Barrera, Adelaeda; Morales-Loredo, Humberto; Garcia, Joshua; Fregoso, Gisel; Pace, Carolyn E.; Mendiola, Perenkita J; Naik, Jay S.; Bosc, Laura V. González; Kanagy, Nancy L.

doi:10.1152/ajpheart.00672.2019

Cited by 6 publications

(1 citation statement)

References 41 publications

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“…There are a number of studies that suggest additional levels of hypoxic regulation of H 2 S and homeostasis in the vasculature. Intermittent hypoxia associated with sleep apnea decreases CSE and H 2 S in resistance arterioles resulting in increased vascular resistance [ 149 ]. Administration of H 2 S to rats with hypoxic pulmonary hypertension (HPH) inhibits the expression of elastin in its extracellular matrix, which also has remarkable regulatory function in forming HPH and remodeling hypoxic pulmonary vascular structure [ 150 ].…”

Section: Evidence For H 2 S Mediated O 2 Sensing In Various Organ Systems and Tissuesmentioning

confidence: 99%

A Case for Hydrogen Sulfide Metabolism as an Oxygen Sensing Mechanism

Olson

2021

Antioxidants

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The ability to detect oxygen availability is a ubiquitous attribute of aerobic organisms. However, the mechanism(s) that transduce oxygen concentration or availability into appropriate physiological responses is less clear and often controversial. This review will make the case for oxygen-dependent metabolism of hydrogen sulfide (H2S) and polysulfides, collectively referred to as reactive sulfur species (RSS) as a physiologically relevant O2 sensing mechanism. This hypothesis is based on observations that H2S and RSS metabolism is inversely correlated with O2 tension, exogenous H2S elicits physiological responses identical to those produced by hypoxia, factors that affect H2S production or catabolism also affect tissue responses to hypoxia, and that RSS efficiently regulate downstream effectors of the hypoxic response in a manner consistent with a decrease in O2. H2S-mediated O2 sensing is then compared to the more generally accepted reactive oxygen species (ROS) mediated O2 sensing mechanism and a number of reasons are offered to resolve some of the confusion between the two.

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Section: Evidence For H 2 S Mediated O 2 Sensing In Various Organ Systems and Tissuesmentioning

confidence: 99%

A Case for Hydrogen Sulfide Metabolism as an Oxygen Sensing Mechanism

Olson

2021

Antioxidants

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Taking to “heart” the proposed legislation for permanent daylight saving time

Carter

Knutson

Mokhlesi

2022

American Journal of Physiology-Heart and Circulatory Physiology

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In March 2022, the United States Senate passed the Sunshine Protection Act that would abolish the biannual change in clocks each fall and spring, and permanently adopt daylight saving time that aligns with the 'spring forward' time change each March. A number of scientific and medical societies have endorsed the abolishment of the biannual clock change, but oppose the permanent adoption of daylight saving time. Instead, leading organizations such as the American Academy of Sleep Medicine (AASM) and the Society for Research on Biological Rhythms (SRBR) position statements highlight peer-reviewed evidence in favor of a permanent shift to standard time. The present perspectives will summarize some of the key AASM and SRBR recommendations, with a particular focus on the potential cardiovascular implications of a legislative change that would result in a permanent switch to either standard time or daylight saving time. Collectively, while there is building scientific consensus that abolishing the biannual time change has several sleep and circadian health benefits, the preponderance of evidence is opposite to the current legislation - and instead suggests a permanent switch to standard time may offer the maximum health and safety benefits. This scientific evidence should be considered as the United States House of Representatives considers the Sunshine Protection Act.

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Sympathetic neural responses to sleep disorders and insufficiencies

Greenlund

Carter

2022

American Journal of Physiology-Heart and Circulatory Physiology

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Short sleep duration and poor sleep quality are associated with cardiovascular risk, and sympathetic nervous system (SNS) dysfunction appears to be a key contributor. The present review will characterize sympathetic function across several sleep disorders and insufficiencies in humans, including sleep deprivation, insomnia, narcolepsy, and obstructive sleep apnea (OSA). We will focus on direct assessments of sympathetic activation (e.g., plasma norepinephrine and muscle sympathetic nerve activity), but include heart rate variability (HRV) when direct assessments are lacking. The review also emphasizes sex as a key biological variable. Experimental models of total sleep deprivation and sleep restriction are converging to support epidemiological studies reporting an association between short sleep duration and hypertension, especially in women. A systemic increase of SNS activity via plasma norepinephrine is present with insomnia, and has also been confirmed with direct, regionally-specific evidence from microneurographic studies. Narcolepsy is characterized by autonomic dysfunction via both HRV and microneurographic studies, but with opposing conclusions regarding SNS activation. Robust sympathoexcitation is well documented in OSA, and is related to baroreflex and chemoreflex dysfunction. Treatment of OSA with continuous positive airway pressure results in sympathoinhibition. In summary, sleep disorders and insufficiencies are often characterized by sympathoexcitation and/or sympathetic/baroreflex dysfunction, with several studies suggesting women may be at heightened risk.

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Simulated sleep apnea alters hydrogen sulfide regulation of blood flow and pressure

Abstract: These results suggest that CSE’s protective role in the vasculature is impaired by simulated sleep apnea, which also upregulates CSE in the carotid body. Thus, this enzyme system can exert both pro- and antihypertensive effects and may contribute to elevated SNS outflow in sleep apnea.

Cited by 6 publications

References 41 publications

A Case for Hydrogen Sulfide Metabolism as an Oxygen Sensing Mechanism

A Case for Hydrogen Sulfide Metabolism as an Oxygen Sensing Mechanism

Taking to “heart” the proposed legislation for permanent daylight saving time

Sympathetic neural responses to sleep disorders and insufficiencies

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