Deuterium gas-puff z-pinches are researched primarily as efficient sources of DD fusion neutrons. The first experiment with a deuterium gas jet was carried out in 1978 (J. Shiloh, A. Fisher, and N. Rostoker, Phys. Rev. Lett. 40, 515518, 1978). Since then, several D2 gas-puff experiments have been performed on various pulsed-power generators. The highest, so far published, DD neutron yields of 4×1013 were observed on the Z-machine at Sandia National Laboratories around 2005 (C.A. Coverdale, et al. Phys. Plasmas 14, 022706, 2007). More recently, z-pinch experiments with a plasma shell on a deuterium gas puff were carried out on GIT-12 higher-impedance pulsed-power generator at 3 MA currents. On GIT-12, unique results were high neutron and ion energies, which approached 60 MeV. Comparison of deuterium gas-puff experiments on different generators allows the identification of the parameters essential for optimizing neutron production. These parameters include the optimal mass, preionization, short deuterium gas-injection time, and zippering towards a cathode. Neutron yields appear to depend not only on a current, but also on other parameters of a generator, such as an impedance and the energy stored in a capacitor bank. Our conclusions regarding the optimal conditions were tested on the Hawk generator (NRL, Washington, DC). At a current of 0.7 MA, Hawk accelerated deuterons up to 15 MeV producing one neutron pulse with the yield of the order of 1010 and a broad energy spectrum in the axial and radial direction. These results show that ion acceleration mechanisms in deuterium gas-puff z-pinches could be very efficient and attractive, with a variety of potential applications in high-energy-density physics, materials science, and controlled thermonuclear fusion research.