Hybrid structures based on TiO 2 nanoparticles and quantum dots (QDs) are effective electron-transfer systems. Here, we report the results of the investigation of photoinduced electron-transfer efficiency in these multilayered hybrid structures, taking into account the resulting multiexponential PL decay of QDs and ROS generation efficiency by the structures. We demonstrate the inhomogeneity of electron-transfer rate in the structures and discuss some reasons for this phenomenon. In this work, for the first time, we estimate electron-transfer efficiency in the TiO 2 /QDs hybrid structures using ROS generation under visible light. We show that the photoinduced electron transfer is the main reason for QD quenching in hybrid TiO 2 -based nanoparticles and propose a way to improve the efficiency of these structures.