Simulation and Analysis of Microparticles Acoustophoretic Separation in Multi-Channel Lab-Chip Device

Klymkovych, Tamara; Bokla, Nataliia; Matviykiv, Oleh; Stakhiv, Volodymyr

doi:10.1109/cadsm52681.2021.9385236

Cited by 1 publication

(2 citation statements)

References 9 publications

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“…These waves consist of a longitudinal compression motion coupled with a transversal shear motion [8]. It should be noted that bulk acoustic wave devices generated by substrate-bonded bulk transducers are outside the scope of this work due to their unsuitability for microfluidic devices and high operating frequency and energy requirements [8,19,75]. When a surface standing acoustic wave (SSAW) is applied between the opposite walls of the channel (which act as reflectors) by exciting the piezoelectric elements, a harmonic standing pressure field is formed in the fluid.…”

Section: Acoustic Forcesmentioning

confidence: 99%

“…More specifically, TSAWs are waves that propagate in one direction and push the dispersed particles/cells in the direction of propagation. In contrast, SSAWs are formed in the volume of the microchannel as a result of the superposition of two traveling waves, which move towards each other and have some phase shift [75]. The design and electrical signal applied to IDTs completely defines the frequency, amplitude, and orientation of the generated acoustic waves; however, the microchannel dimensions and layout, together with its material and liquid phase composition, will affect the acoustic wave propagation and fluid-particle interaction [75].…”

Section: Acoustic Forcesmentioning

confidence: 99%

See 1 more Smart Citation

Novel Approaches Concerning the Numerical Modeling of Particle and Cell Separation in Microchannels: A Review

Karampelas¹,

Gómez-Pastora

2022

Processes

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The demand for precise separation of particles, cells, and other biological matter has significantly increased in recent years, leading to heightened scientific interest in this topic. More recently, due to advances in computational techniques and hardware, numerical simulations have been used to guide the design of separation devices. In this article, we establish the theoretical basis governing fluid flow and particle separation and then summarize the computational work performed in the field of particle and cell separation in the last five years with an emphasis on magnetic, dielectric, and acoustic methods. Nearly 70 articles are being reviewed and categorized depending on the type of material separated, fluid medium, software used, and experimental validation, with a brief description of some of the most notable results. Finally, further conclusions, future guidelines, and suggestions for potential improvement are highlighted.

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