In this study we consider the flow over airfoils with leading-edge roughness, designed to mimic the ice depositions that may occur on an aircraft in flight. The focus of this investigation is the effect of the angle of attack on the mean-flow three-dimensionality. In our previous work (Kumar et al., Journal of Turbulence, Vol. 22, No. 11, 2021, pp. 735–760), we found stationary spanwise inhomogeneities in the form of alternating regions of fast- and slow-moving fluid, which were termed “flow channels.” In the present study we investigate further this phenomenon. We observe the formation of hairpin vortices downstream of the roughness elements, which eventually merge; this causes the formation of wider channels that remain coherent and affect the trailing-edge separation. With increasing angle of attack, the intensity of flow channeling can increase or decrease depending on the topology of the leading-edge roughness. Its effect on the trailing-edge separation remains, however, significant. The mean-separation line is highly distorted, and the separation length can vary by up to 30% of the chord length along the span.