Simulation and Experiment of Polarized Light Propagating in Anisotropic Tissue

Tianliang, 云天梁 Yun; Nan, 曾楠 Zeng; Wei, 李伟 Li; hui, 马辉 Ma

doi:10.3788/aos20092907.1926

Cited by 3 publications

(2 citation statements)

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“…There are still many problems in the clinical application of existing polarization detection methods. Polarized light microscopy can provide information on tissue morphology by spectroscopic analysis of the polarization properties of backscattered light, but multiple optical scattering in biological tissues leads to significant loss of polarized signals and limits imaging depth [5] . Polarization coherent Raman scattering imaging can only image thin sections or transparent cultured cells.…”

Section: Introductionmentioning

confidence: 99%

Non-contact anisotropy detection based on polarized photoacoustic remote sensing microscopy

Shang,

Long,

et al. 2023

Advanced Optical Imaging Technologies VI

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As a key and unique feature, anisotropy is the variability of material properties in different directions caused by molecular conformation and structural arrangement. The optical properties of anisotropic materials include birefringence and dichroism, and the characterization of these properties can be used to detect changes in the microstructure of materials. Conventional polarized optics imaging and photoacoustic imaging are based on scattering and contact measurements respectively, limiting many applications. Photoacoustic remote sensing (PARS) is an all-optical, non-contact photoacoustic measurement technique that provides specific light absorption contrast without coupling or labeling. However, PARS usually ignores tissue uptake anisotropy, which may result in missing some unique tissue properties and information. To obtain more dimensional information on targets, here we propose polarized photoacoustic remote sensing (P-PARS) microscopy. The system uses linearly polarized light in different directions as the excitation source and indicates the anisotropic optical absorption of the target by detecting changes in the reflected intensity of the interrogation light. It can simultaneously provide images of optical absorption contrast and the degree of anisotropy. Experimental results of testing materials and biological tissues demonstrated the feasibility and stability of the P-PARS. This method provides a new noncontact label-free strategy for anisotropy detection, prefiguring important potential for anisotropic material inspection and biological tissue imaging.

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Section: Introductionmentioning

confidence: 99%

Non-contact anisotropy detection based on polarized photoacoustic remote sensing microscopy

Shang,

Long,

et al. 2023

Advanced Optical Imaging Technologies VI

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“…生物体结构的有序性是生命现象的基础, 一旦发生异常, 往往导致疾病的产生. 例如, 肿瘤细胞基质中胶原纤维的含量和有序性与肿瘤的侵袭性密切相关 [13] ; 神经退行性疾病和动脉粥样硬化中出现的淀粉样斑块, 其分子具有明显的各向异性特征 [14,15] ; 此外, 肝纤维化、心肌坏死等疾病都伴随着组织结构各向异性的改变 [16] . 因此, 监测生物为光在生物组织传播存在较强的散射 [17] , 这会导致信号的衰减和退极化, 限制了成像深度和分辨率, 增加了数据分析的复杂度.…”

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Research and development of polarized photoacoustic imaging technology

Liu,

Chen,

Yang

et al. 2023

Acta Phys. Sin.

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Life is a highly ordered combination, and the basic biological processes of cells and tissues are essentially controlled by the structural order of biomolecular assembly, in which the conformational characteristics of biomolecules, such as arrangement, orientation, helix, and folding, are closely related to the physiological functions of biological tissues. In the skin, muscle, and nerve tissues of living animals, for instance, fibrous proteins, collagen, nerve fibers, and DNA frequently exhibit molecular spatial conformation properties such as particular alignment or helical structure, and such tissues have distinct optical polarization responses. The fundamental structural foundation for tissues to carry out certain activities is provided by molecular conformational characteristics. Early illness diagnosis will be aided by the accurate detection and efficient revelation of molecular conformational characteristics and their alterations. The microscopic organization, structure, orientation, chirality, and other structural details of living things or materials can be obtained using polarization imaging. The analysis of the imaging depth and polarization data is challenging, despite its widespread usage in the fields of material detection and biological imaging. Photoacoustic imaging preserves both the great contrast of optical imaging and the deep penetration of ultrasonic imaging by using light as the excitation source and ultrasound as the carrier for information transmission. While keeping the benefits of non-invasiveness, it is capable of high-resolution imaging, deep penetration, and functional imaging. A polarized photoacoustic imaging technology has recently been developed to complement polarization optical imaging and allow the collection of three-dimensional polarization data from deeper layers of the medium. This offers a straightforward and efficient method for measuring the polarimetry of tissues, suggesting substantial promise for both biological imaging and substance detection. The evolution of polarized photoacoustic imaging technology is outlined in this publication. First, the technical underpinnings of polarized photoacoustic imaging are described. Then, from the two application fields of biological tissue imaging and nanomaterial detection, the related research progress of polarized photoacoustic microscopic imaging, polarized photoacoustic computational tomography, and Polarized photoacoustic nanoparticles' molecular imaging is presented. We briefly explain the depolarization that results from particle size, density, and organization as polarized light travels through tissue. In anisotropic media, the change in the mid-incident polarization state of such a sample is caused by tissue birefringence and scattering because of the inherent birefringence effect of molecules, whereas in isotropic media, depolarization is largely determined by the density and size of the scatterer. The potential applications of polarized photoacoustic imaging are then discussed.

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Change of the polarization properties of the human dermis with directions of incident and observation

Gao

Chang

2023

Optics and Lasers in Engineering

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Simulation and Experiment of Polarized Light Propagating in Anisotropic Tissue

Cited by 3 publications

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Non-contact anisotropy detection based on polarized photoacoustic remote sensing microscopy

Non-contact anisotropy detection based on polarized photoacoustic remote sensing microscopy

Research and development of polarized photoacoustic imaging technology

Change of the polarization properties of the human dermis with directions of incident and observation

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