Multiple ducts in the working shaft and main body of tunnels form a combined tee structure. An efficient and accurate prediction method for the local resistance coefficient is the key to the design and optimization of the maintenance ventilation scheme. However, most existing studies use numerical simulations and model experiments to analyze the local resistance characteristics of specific structures and calculate the local resistance coefficient under specific ventilation conditions. Therefore, there are shortcomings of low efficiency and high cost in the ventilation scheme optimization when considering the influence of the local resistance. This paper proposes a hybrid prediction model for the local resistance coefficient of water transmission tunnel maintenance ventilation based on machine learning. The hybrid prediction model introduces the hybrid kernel into a relevance vector machine to build the hybrid kernel relevance vector machine model (HKRVM). The improved artificial jellyfish search algorithm (IAJS), which utilizes Fuch chaotic mapping, lens-imaging reverse learning, and adaptive hybrid mutation strategies to improve the algorithm performance, is applied to the kernel parameter optimization of the HKRVM model. The results of a case study show that the method proposed in this paper can achieve the efficient and accurate prediction of the local resistance coefficient of maintenance ventilation and improve the prediction accuracy and prediction efficiency to a certain extent. The method proposed in this paper provides a new concept for the prediction of the ventilation local resistance coefficient and can further provide an efficient prediction method for the design and optimization of maintenance ventilation schemes.