In traditional heavy truck design process, a large number of real vehicle tests are required to evaluate the ride comfort of the heavy truck. This not only increases the R&D costs but also prolongs the R&D cycle, which brings great inconvenience. This paper establishes a three-dimensional digital model in Adams/car based on the relevant parameters of a hybrid heavy truck. The ride comfort with different speeds was tested on B-level random roads and A-level impulsive roads, and the maximum body vibration acceleration of the heavy truck when driving on A-level impulse roads, weighted root mean square value of acceleration of driving seat vibration when driving on a B-level random road are obtained with different speeds. These values reflect the impact on human comfort and health when driving, provide a theoretical basis for the subsequent optimization design and greatly save manpower and material resources.