Prosthetic running blades offer a solution for individuals with disabilities to engage in sports, benefiting them both psychologically and physiologically. Furthermore, a good prosthetic running blade in terms of performance and cost is rarely available to all disabled persons. In this study, we have examined how various materials impact the static behavior of the prosthetic running blade. A finite element numerical analysis was conducted on a prosthetic design to investigate this effect. We have used different materials for investigation such as aluminum alloy (2024 T4), stainless steel (AISI 316), carbon fiber, and titanium alloy (grade 5), under different load conditions. The load conditions have been varied mainly to three conditions, namely, rest (700 N), walking (1400 N), and running (2100 N). In our experimental design, we studied total deformation, equivalent stress, and strain energy to understand the performance based on material choice. It was noticed that the aluminum alloy (2024 T4) blade goes under much deformation when compared to titanium- and carbon fiber-made running blades. The least amount of overall deformation occurs in carbon fiber under varying load conditions. Carbon fiber appears to be the most profitable option due to its lowest cost per running blade. Titanium alloy grade 5, carbon fiber, AISI 316 stainless steel, and aluminum 2024 T4 alloy cost a total of 78.1, 48.5, 67.6, and 20.9 USD, respectively. It is evident that titanium alloy materials carry a higher price compared to alternative materials.