The simulation of the ventilation and the heating, ventilation, and air conditioning (HVAC) systems of vehicles could be used in the energy demand management of vehicles besides improving the air quality inside their cabins. Moreover, traveling by public transport during a pandemic is a concerning factor, and analysis of the vehicle’s cabin environments could demonstrate how to decrease the risk and create a safer journey for passengers. Therefore, this article presents airflow analysis, air changes per hour (ACH), and respiration aerosols’ trajectory inside three vehicles, including a typical car, bus, and airplane. In this regard, three vehicles’ cabin environment boundary conditions and the HVAC systems of the selected vehicles were determined, and three-dimensional numerical simulations were performed using computational fluid dynamic (CFD) modeling. The analysis of the airflow patterns and aerosol trajectories in the selected vehicles demonstrate the critical impact of inflow, outflow, and passenger’s locations in the cabins. The CFD model results exhibited that the lowest risk could be in the airplane and the highest in the bus because of the location of airflows and outflows. The discrete CFD model analysis determined the ACH for a typical car of about 4.3, a typical bus of about 7.5, and in a typical airplane of about 8.5, which were all less than the standard protocol of infection prevention, 12 ACH. According to the results, opening windows in the cars could decrease the aerosol loads and improve the low ACH by the HVAC systems. However, for the buses, a new design for the outflow location or an increase in the number of outflows appeared necessary. In the case of airplanes, the airflow paths were suitable, and by increasing the airflow speed, the required ACH might be achieved. Finally, in the closed (recirculating) systems, the role of filters in decreasing the risk appeared critical.