Simulation of a radiotracer experiment by flow and detection-chain modelling: a first step towards better interpretation

Berne, P.; Thereska, J.

doi:10.1016/j.apradiso.2003.12.010

Cited by 12 publications

(5 citation statements)

References 4 publications

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“…Furthermore, based on its accessible availability and favorable nuclear properties, 99m Tc received considerable attention in multi-disciplinary fields. Recently, it has been involved in a variety of industrial radiotracer applications (Fauquex et al, 1983;Kantzas et al, 2000;Bandeira et al, 2002;Borroto et al, 2003;Berne and Thereska, 2004;Hughes et al, 2004;Thyn and Zitny, 2004;Dash et al, 2012;Pavlovicl et al, 2020). Despite the central role of 99m Tc for different diagnostic medical investigations as well as recent industrial implementations, its limited availability at the usage sites is a real difficulty.…”

Section: Main Photon Energy Kevmentioning

confidence: 99%

New strategies for a sustainable 99mTc supply to meet increasing medical demands: Promising solutions for current problems

Nawar

Türler

2022

Front. Chem.

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The continuing rapid expansion of 99mTc diagnostic agents always calls for scaling up 99mTc production to cover increasing clinical demand. Nevertheless, 99mTc availability depends mainly on the fission-produced 99Mo supply. This supply is seriously influenced during renewed emergency periods, such as the past 99Mo production crisis or the current COVID-19 pandemic. Consequently, these interruptions have promoted the need for 99mTc production through alternative strategies capable of providing clinical-grade 99mTc with high purity. In the light of this context, this review illustrates diverse production routes that either have commercially been used or new strategies that offer potential solutions to promote a rapid production growth of 99mTc. These techniques have been selected, highlighted, and evaluated to imply their impact on developing 99mTc production. Furthermore, their advantages and limitations, current situation, and long-term perspective were also discussed. It appears that, on the one hand, careful attention needs to be devoted to enhancing the 99Mo economy. It can be achieved by utilizing 98Mo neutron activation in commercial nuclear power reactors and using accelerator-based 99Mo production, especially the photonuclear transmutation strategy. On the other hand, more research efforts should be devoted to widening the utility of 99Mo/99mTc generators, which incorporate nanomaterial-based sorbents and promote their development, validation, and full automization in the near future. These strategies are expected to play a vital role in providing sufficient clinical-grade 99mTc, resulting in a reasonable cost per patient dose.

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Section: Main Photon Energy Kevmentioning

confidence: 99%

New strategies for a sustainable 99mTc supply to meet increasing medical demands: Promising solutions for current problems

Nawar

Türler

2022

Front. Chem.

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“…With its ready availability and favorable nuclear properties, 99m Tc is an attractive radiotracer of choice for applications in the industrial sector and is under study by for several industrial applications (Table 3). 8,[35][36][37][38][39][40][41][42][43][44] The 99 Mo/ 99m Tc generator is useful for several industrial tracer technology applications where:…”

Section: Potentially Useful Irg Systemsmentioning

confidence: 99%

Industrial radionuclide generators: a potential step towards accelerating radiotracer investigations in industry

2013

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The novel use of industrial radionuclide generators (IRG) ensures onsite availability of short-lived radionuclides and is expected to contribute significantly to industrial radiotracer investigations. While IRG technology is in its infancy, the use of generator-derived radioisotopes is expected to have broad potential impact on industrial radiotracer investigations. The optimal combination of suitable IRGs and appropriate radiotracer agents will form the basis of such industrial radiotracer investigations. Development of IRGs customized for specific applications is currently under development and the utility of such systems is expected to pave the way for a variety of industry related applications in the areas of residence time distribution (RTD) study, flow rate measurement, leak detection, etc. In this review, we discuss the principles of radionuclide generators, assess major parent/daughter pairs of interest for IRG, and identify the expected utility of potentially useful IRGs. Availability of the parent radionuclides required for IRG fabrication is an important criterion and hence their production is also reviewed. This overview outlines a critical assessment of recent developments, the contemporary status, and key challenges and apertures to the near future. Increase in the knowledge and use of IRGs utilizing available resources will encourage expanded use of these systems for expected future industrial radiotracer studies.Prof. M. R. A.Pillai, PhD, DSc retired as Head, Radiopharmaceuticals Division, BARC in 2013. He worked at the University of Missouri-Columbia as postdoctoral research associate (1987-89) and as visiting professor (1994). He served the IAEA (2003IAEA ( -2010 as a Technical Officer, in which capacity he directed projects on isotopes and radiopharmaceuticals involving 40 countries as well published 14 IAEA documents. He is an Associate Editor of Cancer Biotherapy and Radiopharmaceuticals and is a member of the Editorial Boards of Current Medicinal Chemistry, Current Radiopharmaceuticals and the American Journal of Nuclear medicine and Molecular Imaging. He has authored three books, 130 papers including 10 review articles, and holds two US patents.

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“…In pilot scale industrial systems, the experimentally measured RTD is used to optimize the design parameters and to develop the mathematical model for prediction of the hydrodynamic behavior of the systems. Recent development of radiotracer methodology has also been reported [12]. Recent development of radiotracer methodology has also been reported [12].…”

Section: Introductionmentioning

confidence: 98%

Analysis Of Residence Time Distribution Of Fluid Flow By Axial Dispersion Model

Sugiharto¹,

Su’ud²,

Kurniadi³

et al. 2010

AIP Conference Proceedings

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Simulation of a radiotracer experiment by flow and detection-chain modelling: a first step towards better interpretation

Cited by 12 publications

References 4 publications

New strategies for a sustainable 99mTc supply to meet increasing medical demands: Promising solutions for current problems

New strategies for a sustainable 99mTc supply to meet increasing medical demands: Promising solutions for current problems

Industrial radionuclide generators: a potential step towards accelerating radiotracer investigations in industry

Analysis Of Residence Time Distribution Of Fluid Flow By Axial Dispersion Model

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