Simulation of abdominal aortic aneurysm growth with updating hemodynamic loads using a realistic geometry

Sheidaei, Azadeh; Hunley, Stanley C.; Zeinali‐Davarani, Shahrokh; Raguin, L. Guy; Baek, Seungik

doi:10.1016/j.medengphy.2010.09.012

Cited by 79 publications

(56 citation statements)

References 67 publications

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“…During the progression for Case 1B, a similar trend was seen. These results are in agreement with the results of Sheidaei [36,37] which indicate that the region of higher expansion correlates with regions of a low WSS. Figure 15 shows the direction of WSSvectors at p2, p3, and p4.…”

Section: Simulation Resultssupporting

confidence: 92%

Numerical Simulation in Ulcer-Like Projection due to Type B Aortic Dissection with Complete Thrombosis Type

Mori¹,

Ohtake²,

Watanabe³

et al. 2013

Aortic Aneurysm - Recent Advances

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Section: Simulation Resultssupporting

confidence: 92%

Numerical Simulation in Ulcer-Like Projection due to Type B Aortic Dissection with Complete Thrombosis Type

Mori¹,

Ohtake²,

Watanabe³

et al. 2013

Aortic Aneurysm - Recent Advances

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“…We recognize, of course, that additional complexities must be addressed in future studies, but note that such complexities may only serve to increase further the predicted evolution of regional and temporal variations in AAA properties owing to complex luminal geometries, disturbed blood flows and shear stresses [20,46], heterogeneous recruitment and activation of inflammatory mediators and heterogeneous compositions and distributions of intraluminal thrombus [2,7].…”

Section: Discussionmentioning

confidence: 99%

Importance of initial aortic properties on the evolving regional anisotropy, stiffness and wall thickness of human abdominal aortic aneurysms

Wilson

Baek

Humphrey

2012

J. R. Soc. Interface.

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105

109

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Complementary advances in medical imaging, vascular biology and biomechanics promise to enable computational modelling of abdominal aortic aneurysms to play increasingly important roles in clinical decision processes. Using a finite-element-based growth and remodelling model of evolving aneurysm geometry and material properties, we show that regional variations in material anisotropy, stiffness and wall thickness should be expected to arise naturally and thus should be included in analyses of aneurysmal enlargement or wall stress. In addition, by initiating the model from best-fit material parameters estimated for non-aneurysmal aortas from different subjects, we show that the initial state of the aorta may influence strongly the subsequent rate of enlargement, wall thickness, mechanical behaviour and thus stress in the lesion. We submit, therefore, that clinically reliable modelling of the enlargement and overall rupture-potential of aneurysms may require both a better understanding of the mechanobiological processes that govern the evolution of these lesions and new methods of determining the patient-specific state of the pre-aneurysmal aorta (or correlation to currently unaffected portions thereof ) through knowledge of demographics, comorbidities, lifestyle, genetics and future non-invasive or minimally invasive tests.

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“…An introduction to this approach can be found in Taylor & Draney (2004) and Taylor & Figueroa (2009). Recent studies of the haemodynamics of abdominal aortic aneurysms using this approach include Les et al (2010), Sheidaei et al (2011), Stamatopoulos et al (2011) and Suh et al (2011). Such studies can provide a quantitative description of the flow in an aneurysm and the distribution of shear stress along the vessel wall, and may even incorporate the presence of atherosclerotic plaque.…”

mentioning

confidence: 99%

Dynamics of pulsatile flow through model abdominal aortic aneurysms

2014

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To contribute to the understanding of flow phenomena in abdominal aortic aneurysms, numerical computations of pulsatile flows through aneurysm models and a stability analysis of these flows were carried out. The volume flow rate waveforms into the aneurysms were based on measurements of these waveforms, under rest and exercise conditions, of patients suffering abdominal aortic aneurysms. The Reynolds number and Womersley number, the dimensionless quantities that characterize the flow, were varied within the physiologically relevant range, and the two geometric quantities that characterize the model aneurysm were varied to assess the influence of the length and maximal diameter of an aneurysm on the details of the flow. The computed flow phenomena and the induced wall shear stress distributions agree well with what was found in PIV measurements by Salsac et al. (J. Fluid Mech., vol. 560, 2006, pp. 19-51). The results suggest that long aneurysms are less pathological than short ones, and that patients with an abdominal aortic aneurysm are better to avoid physical exercise. The pulsatile flows were found to be unstable to three-dimensional disturbances if the aneurysm was sufficiently localized or had a sufficiently large maximal diameter, even for flow conditions during rest. The abdominal aortic aneurysm can be viewed as acting like a 'wavemaker' that induces disturbed flow conditions in healthy segments of the arterial system far downstream of the aneurysm; this may be related to the fact that one-fifth of the larger abdominal aortic aneurysms are found to extend into the common iliac arteries. Finally, we report a remarkable sensitivity of the wall shear stress distribution and the growth rate of three-dimensional disturbances to small details of the aneurysm geometry near the proximal end. These findings suggest that a sensitivity analysis is appropriate when a patient-specific computational study is carried out to obtain a quantitative description of the wall shear stress distribution.

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Simulation of abdominal aortic aneurysm growth with updating hemodynamic loads using a realistic geometry

Cited by 79 publications

References 67 publications

Numerical Simulation in Ulcer-Like Projection due to Type B Aortic Dissection with Complete Thrombosis Type

Numerical Simulation in Ulcer-Like Projection due to Type B Aortic Dissection with Complete Thrombosis Type

Importance of initial aortic properties on the evolving regional anisotropy, stiffness and wall thickness of human abdominal aortic aneurysms

Dynamics of pulsatile flow through model abdominal aortic aneurysms

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