Simulation of Blood as Fluid: A Review From Rheological Aspects

Kannojiya, Vikas; Das, Arup Kumar; Das, Prasanta Kumar

doi:10.1109/rbme.2020.3011182

Cited by 29 publications

(18 citation statements)

References 104 publications

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“…In a prospective clinical study, by the use of the developed system, we made an optical quantitative analysis of hemodynamics under progressive valvular stenosis. Figure A shows the images of the blood flow field (flow rate: 5 μL/min; venous flow model) under progressive valvular stenosis (physiological stenosis severity from 0 to 21.5%). ,, The results of imaging analysis are shown in Figure B, from which it is clearly seen that valvular stenosis alters regular hemodynamics. ,− The light intensity contour map of the flow field (Figure C) shows that light intensity and distribution in the valvular region and microfluidic chamber are altered under valvular stenosis. Notably, there is an apparent decrease of light intensity in the valvular region, consistent with the results of finite element analysis (Figure C and Figure S1), which indicates the enhancing effect of valvular stenosis on the shear rate.…”

Section: Resultsmentioning

confidence: 99%

“…Bland–Altman analysis and paired T -test were performed using GraphPad Prism version 8. A standard finite element method was used to solve the Navier–Stokes equations numerically. ,, The fluid medium was considered homogeneous with a constant density of ρ = 1.05 × 10 3 kg/m 3 and a constant viscosity of 4.0 × 10 –3 Pa·s. , …”

Section: Methodsmentioning

confidence: 99%

“…A standard finite element method was used to solve the Navier−Stokes equations numerically. 49,54,55 The fluid medium was considered homogeneous with a constant density of ρ = 1.05 × 10 3 kg/m 3 and a constant viscosity of 4.0 × 10 −3 Pa•s. 17,49 ■ RESULTS AND DISCUSSION Mechanical Regulation for Adjustable Stenosis.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

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Valve-Adjustable Optofluidic Bio-Imaging Platform for Progressive Stenosis Investigation

Liu

et al. 2023

ACS Sens.

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The clinical evidence has proven that valvular stenosis is closely related to many vascular diseases, which attracts great academic attention to the corresponding pathological mechanisms. The investigation is expected to benefit from the further development of an in vitro model that is tunable for biomimicking progressive valvular stenosis and enables accurate optical recognition in complex blood flow. Here, we develop a valve-adjustable optofluidic bio-imaging recognition platform to fulfill it. Specifically, the bionic valve was designed with in situ soft membrane, and the internal air-pressure chamber could be regulated from the inside out to bio-mimic progressive valvular stenosis. The developed imaging algorithm enhances the recognition of optical details in blood flow imaging and allows for quantitative analysis. In a prospective clinical study, we examined the effect of progressive valvular stenosis on hemodynamics within the typical physiological range of veins by this way, where the inhomogeneity and local enhancement effect in the altered blood flow field were precisely described and the optical differences were quantified. The effectiveness and consistency of the results were further validated through statistical analysis. In addition, we tested it on fluorescence and noticed its good performance in fluorescent tracing of the clotting process. In virtue of theses merits, this system should be able to contribute to mechanism investigation, pharmaceutical development, and therapeutics of valvular stenosis-related diseases.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: ■ Materials and Methodsmentioning

confidence: 99%

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Valve-Adjustable Optofluidic Bio-Imaging Platform for Progressive Stenosis Investigation

Liu

et al. 2023

ACS Sens.

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“…We believe that the viscosity of blood cannot be ignored in fluid calculations. In this study, we chose the Carreau model to simulate the non‐Newtonian characteristics of blood 27 . This model can be written as

η (γ ̇) = η_{\infty} + (η_{0} - η_{\infty}) {([], 1 goodbreak+ {(λγ ̇)}^{2})}^{(n - 1) / 2}

where η 0 and η ∞ are the low and high shear viscosity, respectively ( η 0 = 0.056 Pa s, η ∞ = 0.00345 Pa s).…”

Section: Methodsmentioning

confidence: 99%

“…In this study, we chose the Carreau model to simulate the non-Newtonian characteristics of blood. 27 This model can be written as…”

Section: Materials Propertiesmentioning

confidence: 99%

Hemodynamic study on the therapeutic effects of varying diameter embolic coils in the treatment of intracranial aneurysms

Ren,

Li,

et al. 2024

Numer Methods Biomed Eng

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Endovascular coiling is the predominant method for treating cerebral aneurysms. Extensive reports on selecting coil length, hardness, and material are available. However, the impact of coil diameter on postoperative outcomes remains unclear. This study enrolled six personalized geometric models of intracranial aneurysms: three bifurcation aneurysms and three sidewall aneurysms. Four coil models were constructed by changing the coil diameter. Coil embolization was simulated using the finite element method. Computational fluid dynamics was used to characterize hemodynamics in the aneurysms after embolization. Evaluation parameters included velocity reduction, wall shear stress (WSS), low WSS (LWSS), oscillatory shear index (OSI), relative residence time (RRT), and residual flow volume in the aneurysms. At the peak time (t = 0.17 s), the proportion of LWSS area in bifurcation aneurysms increase with the rise in coil diameter: 0.8D, 71.28 ± 12.62% versus 1D, 74.97 ± 19.17% versus 1.2D, 78.88 ± 18.56% versus 1.4D, 84.00 ± 11.53% (mean ± SD). The proportion of high OSI area decreases as the coil diameter increases: 0.8D, 4.41% ± 2.82% versus 1.0D, 3.78 ± 3.33% versus 1.2D, 2.28% ± 1.77% versus 1.4D, 1.58% ± 1.11% (mean ± SD). The proportion of high RRT area increases as the coil diameter rises: 0.8D, 3.40% ± 1.68% versus 1.0D, 7.67 ± 4.12% versus 1.2D, 9.84% ± 9.50% versus 1.4D, 22.29% ± 14.28% (mean ± SD). Side wall aneurysms do not exhibit the aforementioned trend. Bifurcation aneurysms plugged with a coil of 1.4 times the diameter have the largest RFVs (<10 mm/s) within the group. Aforementioned patterns are not found in sidewall aneurysms. In the treatment of aneurysms with coiling, varying coil diameters can result in different hemodynamic environments within the aneurysm. Larger coil diameters have improved hemodynamic performance for bifurcation aneurysms. However, coil diameter and embolization effectiveness have no significant relationship for sidewall aneurysms.

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Numerical modelling of the interaction between dialysis catheter, vascular vessel and blood considering elastic structural deformation

Chen,

Zheng,

Tong

et al. 2024

Numer Methods Biomed Eng

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The dialysis catheter indwelling in human bodies has a high risk of inducing thrombus and stenosis. Biomechanical research showed that such physiological complications are triggered by the wall shear stress of the vascular vessel. This study aimed to assess the impact of CVC implantation on central venous haemodynamics and the potential alterations in the haemodynamic environment related to thrombus development. The SVC structure was built from the images from computed tomography. The blood flow was calculated using the Carreau model, and the fluid domain was determined by CFD. The vascular wall and the CVC were computed using FEA. The elastic interaction between the vessel wall and the flow field was considered using FSI simulation. With consideration of the effect of coupling, it was shown that the catheter vibrated in the vascular systems due to the periodic variation of blood pressure, with an amplitude of up to 10% of the vessel width. Spiral flow was observed along the catheter after CVC indwelling, and recirculation flow appeared near the catheter tip. High OSI and WSS regions occurred at the catheter tip and the vascular junction. The arterial lumen tip had a larger effect on the WSS and OSI values on the vascular wall. Considering FSI simulation, the movement of the catheter inside the blood flow was simulated in the deformable vessel. After CVC indwelling, spiral flow and recirculation flow were observed near the regions with high WSS and OSI values.

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Simulation of Blood as Fluid: A Review From Rheological Aspects

Cited by 29 publications

References 104 publications

Valve-Adjustable Optofluidic Bio-Imaging Platform for Progressive Stenosis Investigation

Valve-Adjustable Optofluidic Bio-Imaging Platform for Progressive Stenosis Investigation

Hemodynamic study on the therapeutic effects of varying diameter embolic coils in the treatment of intracranial aneurysms

Numerical modelling of the interaction between dialysis catheter, vascular vessel and blood considering elastic structural deformation

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