Nonproportionality in fatigue is a matter of loading sequences acting on structures. In such loading cases, a life assessment‐based search of the initiation site is required. This means that for a variety of potential sites, their stress‐strain sequences must be determined and the corresponding fatigue lives have to be calculated. For the determination of local stress‐strain sequences, a superposition of the action of loads at all times for all potential sites must be performed. The superposition has not only to be performed at a particular time of a load reversal but also for a sufficiently large number of intermediate points in time. For the assessment of crack initiation under local nonproportional stress‐strain sequences, a multiaxial fatigue damage hypothesis must be specified. Due to the superiority with respect to accuracy, critical plane approaches are the favourite ones when dealing with nonproportional fatigue of ductile metals. For describing fatigue crack growth, the time sequences for the stress intensity factors corresponding to the 3 opening modes must be obtained by superposition. A mixed‐mode hypothesis must be applied to predict both the direction and the increment of crack growth at each crack front point. A first prediction trial should be based on an appropriate extension of the maximum tangential stress hypothesis. An application of a variant of the maximum shear stress hypothesis might be an amendment. Especially in the case of crack turning, the consideration of crack face contact is mandatory.