In situ NbC-reinforced laser cladding Ni45 coatings have the advantages of high bond strengths, low dilution rates, small heat-affected zones and good wear resistance and have broad application prospects in the field of surface strengthening and repair of workpieces such as automotive molds and engine turbines. Previous studies have mostly used pure niobium powder for in situ synthesis to prepare Ni-based NbC coatings with a high production cost. In this paper, NbC was successfully synthesized in situ in Ni45 powder using inexpensive FeNb65 and Cr3C2. The prepared coating has a uniform microstructure and excellent wear resistance, and the reinforced phases are mainly NbC and Cr23C6. Coating 4# with 25 wt.% FeNb65 + Cr3C2 has the highest microhardness of 776.3HV0.2, about 1.45 times that of the Ni45 coating, and its wear resistance is 36.36 min/mg, about 60.6 times that of the Cr12MoV steel base material and about 23.76 times that of the Ni45 coating.