Many studies were focused on the effect of fusion plasma particles onto the structural materials of future nuclear fusion reactor. In this paper, the effect of the products of the first generation fuel reaction on structural fusion materials as copper and 316-stainless steel target materials was studied. Firstly, the effect of 14.1 MeV neutrons produced from D-T neutron generator for different irradiation time equal to 10, 20, 30, 50 and 60 minutes was investigated. Hence, this effect was analyzed and characterized by X-ray diffration analysis, surface roughness tester, scanning electron microscope and Vickers hardness. Secondly, the effect of 3.5 MeV α-particles on these target materials by different incident angles equal to 0°, 30°, 45°, 60° and 85° using SRIM code was studied. Also, SRIM code was used for calculation α-particles trajectories, projected and straggle ranges, skewness, kurtosis, target ionization / phonons and total displacements for copper and 316- stainless steel target materials.