The spatial plan program for Makassar City and the surrounding area called Mamminasata (Makassar, Maros, Sungguminasa, and Takalar) was created by the Indonesian Government. The program regulates the proportion of land cover, but predictions about land cover changes were not considered. Therefore, in this study, we predict what the land cover may be in 2031 using the multi-layer perceptron neural network and the Markov chain methods. For this purpose, image composite, support vector machine classifier, and change detection were applied to a time series of satellite data. Visual validation showed the hot-spots of land cover changes related to population density, and statistical validation scored 0.99 and 0.78 in no information kappa and grid-cell level location kappa, respectively. The model was performed to predict land cover in 2031, and the predicted result was then compared with the spatial plan using an overlapping method. The results showed that built-up area, dryland agriculture, and wetland agriculture occupied two, twenty, and eight percent of the protected zone, respectively. Meanwhile, fifteen percent of the development zone was covered by forest, mainly in the eastern part of Mamminasata. The result can be used to help the Government decide future plans for the Mamminasata area.