Simulation of laser backscattering system for imaging of inhomogeneity/tumor in biological tissues

Jeeva, J. B.; Singh, Megha

doi:10.1016/j.cmpb.2017.01.010

Cited by 8 publications

(4 citation statements)

References 35 publications

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“…The spatially resolved reflectance measurement is a part of fast-growing optical technology to detect inhomogeneities in healthy tissues and is supported by analytical techniques. Such a measurement can further be extended to six to cover six depths from the surface (38,39) an ideal approach for 3D reconstruction of changes in external and internal tissues (4). The reduction in size of optical components and improvement in power of focused LED may further improve the resolution of the images.…”

Section: Discussionmentioning

confidence: 99%

Optical Scanning System for Imaging of Heterogeneity in Biological Tissues

Christopherjames

Singh³

2022

ECS Trans.

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A non-invasive hand-held optical probe for imaging of biological tissues consists of nine units. Each unit is equipped with one red LED and three photodetectors placed at distances 7, 12, and 17 mm from the source along the x-axis. For testing, three phantoms of paraffin wax are embedded with solid inhomogeneity placed at various depths. Human biological tissues consisting of right index finger, four fingers of the same hand, and a part of the forearm below elbow joint are used. The data on optical backscattering are collected by moving the probe on the surface of phantom/tissue and after processing the respective images are obtained. Three images of the index finger show the tissue structural variation in various layers, which are in agreement with anatomical details and radiograph of the finger. The tissue details of four fingers are in agreement with that of individual finger. Similarly, the three images of the forearm show the structural variation. These observations suggest that the present technique may be used to detect tissue compositional changes below the skin.

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Section: Discussionmentioning

confidence: 99%

Optical Scanning System for Imaging of Heterogeneity in Biological Tissues

Christopherjames

Singh³

2022

ECS Trans.

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“…Initial specular reflectance reduces the photon weight as W photon = 1 − R sp , where R sp = (n t − n m ) 2 /(n t + n m ) 2 with n t representing the refractive index of the tissue and n m the refractive index of the outside medium. n m is set to 1.0 (the refractive index of air), and n t is set to 1.4 (as used in [19], [22], and representing a reasonable average of experimentally measured values (see S4 Table )).…”

Section: Photon Movementmentioning

confidence: 99%

“…However, scar is hardly the only tissue heterogeneity that can cause changes in optical properties: the simulations are agnostic to the physiological cause of the change in optical properties. This can include changes due to the presence of adipose, which is noted to have a substantial effect on optical properties [22], [28], [30], [31], and which can be a substantial component of scar [32].…”

Section: Detection Of Tissue Propertiesmentioning

confidence: 99%

Determining cardiac structure by diffuse reflectance of different wavelengths

Gemmell

Bishop

2021

Preprint

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Catheter ablation in patients suffering from chronic arrhythmias requires detailed knowledge of the underlying cardiac anatomy; such real-time, high resolution mapping is currently unavailable in a clinical setting. We present here preliminary work towards a novel optical strategy based on diffuse optical reflectance to provide quantitative anatomical measurements of the cardiac structure, including tissue thickness and presence of scar. An in-depth literature search is conducted to collate available experimental data regarding optical parameters in cardiac tissue and scar. Computational simulations of photon movement through cardiac tissue using Monte Carlo modelling are performed, with analysis being focussed on the effects on surface emission profiles of (i) optical parameters; (ii) tissue thickness; (iii) presence of scar. Our results demonstrate (i) sensitivity of the approach to changes in optical parameters within tissue, (ii) difference of results depending on light wavelength. These suggest that this can be used to detect cardiac anatomical structure to a depth of ~2 mm, for both thickness of cardiac tissue and presence of scar. This study demonstrates the feasibility of using diffuse optical reflectance to determine cardiac structure, enabling a potential route for high-resolution, real-time structural information to guide catheter ablation and similar surgeries.

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“…A portion of the applications incorporate imaging of human tissues in centimeter thick, estimations of oxygen utilization of muscle, location of tumor in breast tissues, functional brain mapping and localization of organs in thorax region (8)( 14) (15). It has been demonstrated that the backscattered photons arriving closer to the source starts from the tissue layers near surface, while, photons received at further distance emerge from deeper layers (16) as shown in figure 1. In the early phases of cancer, the refractive index of biological tissues gets changed, which prompts an exceptional contrast in optical scattering and that change can be recognized easily by utilizing reflectance compared with other imaging systems which are developed (17) (18).…”

Section: Introductionmentioning

confidence: 99%

Noninvasive Optical Imaging System of Biological Tissues

Kadayat¹,

Jeeva²

2022

ECS Trans.

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The non-invasive optical imaging of biological tissue for the detection of the inhomogeneities is studied using phantom. The proposed system which is based on optical reflectance consists of a scanning probe with four sources and twelve detectors. Every unit furnished with a source and three detectors that are organized in a straight-line design to gather the backscattered photons. Photo-detectors are arranged in four rows and three columns with each source followed by three detectors. The distance between first, second, and third column of detectors with source is kept at 7 mm, 12 mm, and 17 mm respectively to obtain information about inhomogeneities. A phantom is prepared using paraffin wax with inhomogeneities placed at 7 mm, 12 mm, and 17 mm depth. Goat tissue phantom was prepared with muscle with bone placed within the layers of muscle. The probe is placed on the phantom and moved over its surface. Data are collected by the detectors at each location as the probe moves. The data acquired from two distinctive wavelength gives correct information about the range of inhomogeneities.

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Simulation of laser backscattering system for imaging of inhomogeneity/tumor in biological tissues

Cited by 8 publications

References 35 publications

Optical Scanning System for Imaging of Heterogeneity in Biological Tissues

Optical Scanning System for Imaging of Heterogeneity in Biological Tissues

Determining cardiac structure by diffuse reflectance of different wavelengths

Noninvasive Optical Imaging System of Biological Tissues

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