Simulation of the Basilar Membrane Vibration of Endolymphatic hydrops

Lee, Sinyoung; Koike, Takuji

doi:10.1016/j.piutam.2017.08.043

Cited by 12 publications

(11 citation statements)

References 8 publications

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“…In other words, after the Young's modulus had been calculated the first time due to a slightly deformed shape, an updated Young's modulus was used again in the subsequent calculation of the BM Young's modulus until the BM was no longer deformed due to increasing stiffness. Consequently, the BM Young's modulus in Lee and Koike [6] model is stiffer than that in the current model -this value results in a less deformed BM shape than in our study.…”

Section: Deformed Bm Due To the Ehcontrasting

confidence: 51%

“…He showed that increased endolymphatic pressure causes (1) a decline in hearing sensitivity, (2) a shift of the location of the maximal amplitude of the basilar membrane (BM) displacement, and (3) harmonic distortion of the BM. Lee and Koike [6] supported this conclusion via a tapered-box finite element (FE) model. They showed a decreased BM velocity ( V BM ) at low frequency due to prestress applied on the membrane implementing the EH.…”

Section: Introductionmentioning

confidence: 92%

“…As mentioned in the methods, the BM Young's modulus due to the deformed shape was updated for dynamic analysis after applying a static pressure. In contrast, Lee and Koike [6] applied a gradually increasing pressure until 100 Pa on the BM surface resulting in gradual BM deformation. The BM Young's modulus was updated repeatedly.…”

Section: Deformed Bm Due To the Ehmentioning

confidence: 99%

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Relationship between Endolymphatic Hydrops and Symptoms of Meniere Disease in Acoustic Hearing

Lim

Cho

et al. 2021

ORL

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Hypothesis: The endolymphatic hydrops (EH) does not affect hearing loss significantly at low frequencies, whereas the hydrops affects the diplacusis. Background: There have been many arguments whether the EH cause the Meniere disease. Despite a lot of experimental studies to investigate the Meniere disease, there have been little modeling studies, which are helpful to understand the mechanism. Methods: A 3D finite element model of the human cochlea and the middle ear was used for investigation of the relationship between EH and hearing loss at low frequencies and diplacusis (2 specific symptoms of Meniere disease). While the cochlear geometry was simplified as a tapered box shape, the middle ear was based on the real geometry obtained from μCT images. EH is implemented by prestress on the basilar membrane surface in the simulation. Results: The EH did not cause significant hearing loss at low frequencies in both air- and bone-conducted hearing. Rather, this disorder caused a shift in best frequency (BF) position to the base at low frequencies below about 250 Hz. The BF shift can explain the diplacusis because a low-frequency sound can be perceived as a slightly higher frequency so that Meniere patients can perceive 2 different frequency sounds corresponding to a given single-frequency sound. Conclusion: The EH cannot be a sufficient condition for Meniere disease, whereas the hydrops can cause the diplacusis.

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Section: Deformed Bm Due To the Ehcontrasting

confidence: 51%

Section: Introductionmentioning

confidence: 92%

Section: Deformed Bm Due To the Ehmentioning

confidence: 99%

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Relationship between Endolymphatic Hydrops and Symptoms of Meniere Disease in Acoustic Hearing

Lim

Cho

et al. 2021

ORL

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“…Abnormalities or damage in the structure inside the inner ear can result by many diseases that can load to the hearing loss. An example of such a disease is the Alport syndrome [7] and Meniere's disease [8] . For these raisons, many mathematical models have been proposed to model the function and the dysfunction of the inner ear by using partial differential equation (PDEs) [7,8,9,10,11] .…”

Section: Introductionmentioning

confidence: 99%

“…An example of such a disease is the Alport syndrome [7] and Meniere's disease [8] . For these raisons, many mathematical models have been proposed to model the function and the dysfunction of the inner ear by using partial differential equation (PDEs) [7,8,9,10,11] . The epidemiological models in the beginning (1) has started by Graunt [12] then described by Kermack and Mckendric [13] by considering the total population into three classes namely susceptible (S) individuals, infected (I) individuals and recovered (R) individuals which is known to us as SIR epidemic model [14,15,16] .…”

Section: Introductionmentioning

confidence: 99%

Modeling the Social and Epidemiological Causes of Hearing Loss

Kouilily¹,

Yousfi²,

Achtaich³

et al.

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Hearing loss result from genetic causes, complications at birth, certain infectious diseases, chronic ear infections, noise exposure, demographic characteristics (age, sex, race, education, and study site) and cardiovascular factors (smoking status, hypertension, diabetes and stroke). In this study, we propose a new mathematical model formulated by ordinary differential equations (ODEs) that takes into account the some causes of hearing loss. The analysis of the model is investigated. In addition, numerical simulations are presented in order to validate our theoretical results.

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A finite element model to predict the consequences of endolymphatic hydrops in the basilar membrane

Areias

Parente

Gentil³

et al. 2021

Numer Methods Biomed Eng

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Ménière's disease is an inner ear disorder, associated with episodes of vertigo, fluctuant hearing loss, tinnitus, and aural fullness. Ménière's disease is associated with endolymphatic hydrops. Clinical evidences show that this disease is often incapacitating, negatively affecting the patients' everyday life. The pathogenesis of Ménière's disease is still not fully understood and remains unclear. Previous numerical studies available in the literature related with endolymphatic hydrops, are very scarce. The present work applies the finite element method to investigate the consequences of endolymphatic hydrops in the normal hearing, associated with the Ménière's disease. The obtained results for the steady state dynamics analysis are in accordance with clinical evidences.The results show that the basilar membrane is not affected in the same intensity along its length and that the lower frequencies are more affected by the endolymphatic hydrops. From a clinical point of view, this work shows the relationship between the increasing of the endolymphatic pressure and the development of hearing loss.

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Simulation of the Basilar Membrane Vibration of Endolymphatic hydrops

Cited by 12 publications

References 8 publications

Relationship between Endolymphatic Hydrops and Symptoms of Meniere Disease in Acoustic Hearing

Relationship between Endolymphatic Hydrops and Symptoms of Meniere Disease in Acoustic Hearing

Modeling the Social and Epidemiological Causes of Hearing Loss

A finite element model to predict the consequences of endolymphatic hydrops in the basilar membrane

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