Simulation of the Frank-Starling Law of the Heart

Ribarič, Samo; Kordaš, M.

doi:10.1155/2012/267834

Cited by 7 publications

(2 citation statements)

References 21 publications

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“…; Dori et al. ; Ribaric and Kordas ). Altering the preload can be used to assess functional performance, as well as study mechanosensing and excitation‐contractile mechanisms in papillary muscles (Patterson et al.…”

Section: Resultsmentioning

confidence: 98%

Isolated neonatal rat papillary muscles: a new model to translate neonatal rat myocyte signaling into contractile mechanics

et al. 2016

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Isolated cardiac tissue allows investigators to study mechanisms underlying normal and pathological conditions, which would otherwise be difficult or impossible to perform in vivo. Cultured neonatal rat ventricular cardiac myocytes (NRVM) are widely used to study signaling and growth mechanisms in the heart, primarily due to the versatility, economy, and convenience of this in vitro model. However, the lack of a well‐defined longitudinal cellular axis greatly hampers the ability to measure contractile function in these cells, and therefore to associate signaling with mechanical function. In these methods, we demonstrate that this limitation can be overcome by using papillary muscles isolated from neonatal rat hearts. In the methods we describe procedures for isolation of right ventricular papillary muscles from 3‐day‐old neonatal rats and effects of mechanical and humoral stimuli on contraction and relaxation properties of these tissues.

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Section: Resultsmentioning

confidence: 98%

Isolated neonatal rat papillary muscles: a new model to translate neonatal rat myocyte signaling into contractile mechanics

et al. 2016

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“…1 In recent years, more and more studies have showed that goaldirected fluid therapy (GDFT) can provide individual treatment for patients, preventing perioperative patients from potentially hypervolaemia or hypervolaemia and reducing complications or mortality. According to Frank-Starling's curve, 2 the preload of the ventricle is proportional to the cardiac output (CO) in the raising stage. However, if the preload reaches the platform stage, fluid therapy would not yield the desired effect but result in cardiac overload and tissue oedema.…”

Section: Introductionmentioning

confidence: 99%

Stroke volume variation for predicting responsiveness to fluid therapy in patients undergoing cardiac and thoracic surgery: a systematic review and meta-analysis

et al. 2022

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ObjectiveTo evaluate the reliability of stroke volume variation (SVV) for predicting responsiveness to fluid therapy in patients undergoing cardiac and thoracic surgery.DesignSystematic review and meta-analysis.Data sourcesPubMed, EMBASE, Cochrane Library, Web of Science up to 9 August 2020.MethodsQuality of included studies were assessed with the Quality Assessment of Diagnostic Accuracy Studies-2 tool. We conducted subgroup analysis according to different anaesthesia and surgical methods with Stata V.14.0, Review Manager V.5.3 and R V.3.6.3. We used random-effects model to pool sensitivity, specificity and diagnostic odds ratio with 95% CI. The area under the curve (AUC) of receiver operating characteristic was calculated.ResultsAmong the 20 relevant studies, 7 were conducted during thoracic surgery, 8 were conducted during cardiac surgery and the remaining 5 were conducted in intensive critical unit (ICU) after cardiac surgery. Data from 854 patients accepting mechanical ventilation were included in our systematic review. The pooled sensitivity and specificity were 0.73 (95％ CI: 0.59 to 0.83) and 0.62 (95％ CI: 0.46 to 0.76) in the thoracic surgery group, 0.71 (95％ CI: 0.65 to 0.77) and 0.76 (95％ CI: 0.69 to 0.82) in the cardiac surgery group, 0.85 (95％ CI: 0.60 to 0.96) and 0.85 (95％ CI: 0.74 to 0.92) in cardiac ICU group. The AUC was 0.73 (95% CI: 0.69 to 0.77), 0.80 (95% CI: 0.77 to 0.83) and 0.88 (95% CI: 0.86 to 0.92), respectively. Results of subgroup of FloTrac/Vigileo system (AUC=0.80, Youden index=0.38) and large tidal volume (AUC=0.81, Youden index=0.48) in thoracic surgery, colloid (AUC=0.85, Youden index=0.55) and postoperation (AUC=0.85, Youden index=0.63) in cardiac surgery, passive leg raising (AUC=0.90, Youden index=0.72) in cardiac ICU were reliable.ConclusionSVV had good predictive performance in cardiac surgery or ICU after cardiac surgery and had moderate predictive performance in thoracic surgery. Nevertheless, technical and clinical variables may affect the predictive value potentially.

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