Simulation of the hydrodynamic conditions of the eye to better reproduce the drug release from hydrogel contact lenses: experiments and modeling

Pimenta, Andreia; Valente, Andreia; Pereira, Joana; Filipe, Helena Prior; Mata, José L.; Colaço, R.; Saramago, Benilde; Serro, Ana Paula

doi:10.1007/s13346-016-0303-1

Cited by 26 publications

(13 citation statements)

References 28 publications

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“…An increased drug release in the presence of PEGDA hydrogel in the dynamic condition is likely due to the polymer/drug layer in contact with a larger amount of water content in the hydrogel. This is consistent with a finding by Pimenta et al, who compared diclofenac release from hydroxyethyl methacrylate-based hydrogel [49], where 90% diclofenac release was attained by 100 hours in dynamic flow, as compared to 24 hours in static condition.…”

Section: Discussionsupporting

confidence: 92%

A bilayer swellable drug-eluting ureteric stent: Localized drug delivery to treat urothelial diseases

et al. 2018

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Section: Discussionsupporting

confidence: 92%

A bilayer swellable drug-eluting ureteric stent: Localized drug delivery to treat urothelial diseases

et al. 2018

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“…Similarly, because most used ophthalmology in vitro drug release study is carried out under static conditions, and are not fully considering the influence of flow dynamics, need to take into account the tear volume and flow in the body, Pimenta et al [ 104 ] designed a microfluidic unit to simulate the tear continuous, the volumetric flow rate, and its small volume. The release kinetics of a drug system containing diclofenac was compared with that under static condition by using the microfluidic chip, and the results showed that the release kinetics under dynamic condition was slower.…”

Section: In Vitro Biomechanical Study Methods Of Eye Tissuementioning

confidence: 99%

Biomechanical analysis of ocular diseases and its in vitro study methods

Zhao

Yan

et al. 2022

BioMed Eng OnLine

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Ocular diseases are closely related to the physiological changes in the eye sphere and its contents. Using biomechanical methods to explore the relationship between the structure and function of ocular tissue is beneficial to reveal the pathological processes. Studying the pathogenesis of various ocular diseases will be helpful for the diagnosis and treatment of ocular diseases. We provide a critical review of recent biomechanical analysis of ocular diseases including glaucoma, high myopia, and diabetes. And try to summarize the research about the biomechanical changes in ocular tissues (e.g., optic nerve head, sclera, cornea, etc.) associated with those diseases. The methods of ocular biomechanics research in vitro in recent years are also reviewed, including the measurement of biomechanics by ophthalmic equipment, finite element modeling, and biomechanical analysis methods. And the preparation and application of microfluidic eye chips that emerged in recent years were summarized. It provides new inspiration and opportunity for the pathogenesis of eye diseases and personalized and precise treatment.

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“…Since the lack of hydration results in dry eye syndrome [148], it is recommended to use contact lenses in association with eye drops [149].…”

Section: Contact Lensesmentioning

confidence: 99%

Chitosan: A Good Candidate for Sustained Release Ocular Drug Delivery Systems

Popa¹,

Ghica²,

Dinu-Pîrvu³

et al. 2018

Chitin-Chitosan - Myriad Functionalities in Science and Technology

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This chapter focuses on the eye, one of the most important organs of humans. Current data on pathophysiology of the human eye are presented in direct correlation with a range of therapeutic products, with a well-known and widely used material, namely chitosan. Applications of chitosan biopolymer are described in the development of innovative, modern, therapeutic devices and solutions. Thus, chitosan is a good excipient either for classic drop-type ocular systems, as well as for complex drug systems such as nanostructures (nanoparticles, nanomicelles and nanosuspensions), liposomes, microemulsions, microspheres, in situ hydrogels and inserts or implants. A number of disadvantages for ocular administration of the drugs are thus overcome.

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Simulation of the hydrodynamic conditions of the eye to better reproduce the drug release from hydrogel contact lenses: experiments and modeling

Cited by 26 publications

References 28 publications

A bilayer swellable drug-eluting ureteric stent: Localized drug delivery to treat urothelial diseases

A bilayer swellable drug-eluting ureteric stent: Localized drug delivery to treat urothelial diseases

Biomechanical analysis of ocular diseases and its in vitro study methods

Chitosan: A Good Candidate for Sustained Release Ocular Drug Delivery Systems

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