This paper deals with the formulation, development and validation of a newly developed micromechanical-based model for the modeling of the nonlinear ductile fracture of human humerus. The originality of the present works concerns the coupling between the micromechanical formulation based on the Mori-Tanaka homogenization scheme for cylindrical voids and the Marigo nonlinear ductile damage model based on the porosity growth. The proposed model was implemented as a User Material UMAT within the explicit dynamic software LS-DYNA and validated by numerical and experimental analysis conducted by a drop tower impact of human humerus. The outcome of the proposed multi-scale model appears to correctly predict the general trends observed experimentally via the good estimation of the ultimate impact load and the fracture patterns of the human humerus.