Desiccant-based air handling units can achieve reductions in greenhouse gas emissions and energy savings with respect to conventional air conditioning systems. Benefits are maximized when they interact with renewable energy technologies, such as solar collectors. In this work, experimental tests and data derived from scientific and technical literature are used to implement a model of a solar desiccant cooling system, considering three different solar collector technologies (air, flat plate and evacuated collectors). Simulations were then performed to compare the energy, environmental and economic performance of the system with those of a desiccant-based unit in which regeneration thermal energy is supplied by a natural gas boiler, and with a conventional air handling device. The only solution that allows to achieve the economic feasibility of the solar desiccant cooling unit consists of 16 m 2 of evacuated solar collectors. This solution allows to obtain, with respect to the reference system, a reduction of primary energy consumption and of the equivalent CO 2 emissions of 50.2% and 49.8%, respectively, with a pay-back time of 17 years.