Simulation studies of a novel electromagnetic actuation scheme for focusing magnetic micro/nano-carriers into a deep target region

Abstract

The ability to focus spherical particles (SPPs) to a deep tumor region remains one of the major challenges in magnetic drug targeting (MDT). A number of studies have attempted to overcome this problem using fast magnetic pulses and ferromagnetic rods. However, focusing of the SPPs in the deep body organs remains unsolved using existing schemes. In this paper, we propose a novel electro-magnetic actuation scheme for pushing and focusing SPPs. The simulation results demonstrate that the newly proposed actuation scheme can focus SPPs to a target surface region, inside of a block filled with an environment that has the characteristics of blood. We then investigated the effects of the proposed focusing scheme in realistic blood vessels with a maximum length of about 10–12 cm. The results show that SPPs of 500 nm can be concentrated onto a target tumor region with up to 97.9% efficiency. The proposed electromagnetic actuation scheme can maximize the efficiency of MDT, while minimizing the side effects of drugs in other tissues.

In Silico Study to Enhance Delivery Efficiency of Charged Nanoscale Nasal Spray Aerosols to the Olfactory Region Using External Magnetic Fields

“…Only an infinite linear wire was tested in this study. Other configurations of magnetic targeting systems may reveal alternative ways to further improve olfactory drug delivery [ 46 , 47 , 48 ]. Such systems can be further examined in future work.…”

Steering the Drug Release of Smart Magnetic Self-Assembled Nano Micelles in an Internal Thoracic Artery Flow for Breast Cancer Therapy

“…[17]; [8]; [18]. Numerous mathematical models have been developed on the magnetically guided drug delivery systems to investigate the e cacy of MDT [19]; [20]; [21]; [22]. Zhang et al (2020), developed a mathematical model of MDT using ANSYS software to predict the drug particle trajectories by an external magnetic eld for atherosclerosis therapy.…”

“…The model connects the dynamics of spherical drug particles with hydrodynamic modeling of the lattice-Boltzmann taking into account the body's strength, diffusion and dipole interactions [21]. 2017), proposed a novel electro-magnetic push-and-focus spherical particles (SPP) actuation system to a deep tumor region and investigated the effects of the SPP in realistic blood vessels with a maximum length of about 10-12 cm, the simulation results show that the 500 nm SPPs can be concentrated on a target tumor region with up to 97.9% e ciency [22].…”

Studies of Different Swarm Modes for the MNPs Under the Rotating Magnetic Field

“…Dynamic magnetic actuation by electromagnetic systems is also developed to concentrate MNPs in a location of interest [15], [16]. The electromagnetic actuation and permanent magnetic actuation are used to elevate the concentration of nanoparticles in a region of interest [17], [18]. The magnetic scheme to steer swarm of nanoparticles in the multi bifurcations were developed [19], [20].…”