Simulation study of a new racetrack FAIMS analyzer to achieve both high-resolution and high-sensitivity

Fu, Shoushuai; Wang, Chenlu; Li, Junhui; Yu, Jiancheng; Tang, Keqi

doi:10.1016/j.talanta.2024.126305

Talanta

2024

DOI: 10.1016/j.talanta.2024.126305

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Simulation study of a new racetrack FAIMS analyzer to achieve both high-resolution and high-sensitivity

Shoushuai Fu,

Chenlu Wang,

Junhui Li

et al.

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Cited by 2 publications

References 38 publications

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A boundary condition decoupled steady-state equivalent model for the simulation of FAIMS ion optical path

Ji,

Liu,

Wang

et al. 2025

International Journal of Mass Spectrometry

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A boundary condition decoupled steady-state equivalent model for the simulation of FAIMS ion optical path

Ji,

Liu,

Wang

et al. 2025

International Journal of Mass Spectrometry

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Racetrack FAIMS for High-Resolution and High-Sensitivity Characterization of Peptide Conformers

Li,

Liu,

et al. 2024

Anal. Chem.

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A racetrack field asymmetric waveform ion mobility spectrometry (r-FAIMS) device, which consists of both cylindrical FAIMS (c-FAIMS) and planar FAIMS (p-FAIMS) sections with a 1 mm gap width, was developed and applied for high-resolution and high-sensitivity exploration of conformational diversity for peptides. The optimal operating conditions of r-FAIMS were systemically studied, and the performance of the fully optimized r-FAIMS was compared to a previously developed p-FAIMS in detail by using pure nitrogen as the FAIMS carrier gas. Relying on the ion focusing effect in the c-FAIMS section, the intensity of the FAIMS spectrum for doubly charged bradykinin ions acquired by using r-FAIMS is ∼8.5-fold higher than that acquired by using p-FAIMS under the same resolving power/resolution condition, implying about an order of magnitude better sensitivity of r-FAIMS. In addition, the peak separation resolution of r-FAIMS was ∼1.70-fold higher than p-FAIMS under a similar sensitivity condition for doubly charged bradykinin ions. Due to a reduced gap width of the newly designed r-FAIMS (1 mm) as compared to the previously developed p-FAIMS (1.88 mm), r-FAIMS can operate at a much higher separation field with a similar FAIMS dispersion voltage (DV) to gain significantly higher resolving power. For triply charged syntide 2 ions, the resolving power of r-FAIMS can easily exceed 120 at −3.5 kV DV by using pure nitrogen as the FAIMS carrier gas as compared to 44.2 resolving power obtained by using p-FAIMS at −4.0 kV DV. All of the experimental results have confirmed that r-FAIMS can perform structural characterization of biomolecules with both high resolution and high sensitivity.

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Simulation study of a new racetrack FAIMS analyzer to achieve both high-resolution and high-sensitivity

Cited by 2 publications

References 38 publications

A boundary condition decoupled steady-state equivalent model for the simulation of FAIMS ion optical path

A boundary condition decoupled steady-state equivalent model for the simulation of FAIMS ion optical path

Racetrack FAIMS for High-Resolution and High-Sensitivity Characterization of Peptide Conformers

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