Simulation Study of Breast Tissue Hemodynamics During Pressure Perturbation

Nioka, Shoko; Wen, Sihua; Zhang, Jun; Du, Juan; Intes, Xavior; Zhao, Zhongyao; Chance, Britton

doi:10.1007/0-387-26206-7_3

Cited by 16 publications

(10 citation statements)

References 13 publications

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“…Incorporating viscoelastic tissue modelling in NIRS is an approach that has seen some recent activity. Dynamic measurements induced by changes in pressure applied to the tissue can provide a rich dataset for robust, often ratiometric, interpretation of oxygen saturation and total haemoglobin values [106][107][108][109][110][111]. These mechanical models are almost uniformly applied in post-processing or forward modelling [112], owing to the complexity of solving the viscoelastic problem in irregular domains.…”

Section: Prior Information: Biophysical Models (A) Biophysical Modelsmentioning

confidence: 99%

Implicit and explicit prior information in near-infrared spectral imaging: accuracy, quantification and diagnostic value

Pogue

Davis

Leblond

et al. 2011

Phil. Trans. R. Soc. A.

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Near-infrared spectroscopy (NIRS) of tissue provides quantification of absorbers, scattering and luminescent agents in bulk tissue through the use of measurement data and assumptions. Prior knowledge can be critical about things such as (i) the tissue shape and/or structure, (ii) spectral constituents, (iii) limits on parameters, (iv) demographic or biomarker data, and (v) biophysical models of the temporal signal shapes. A general framework of NIRS imaging with prior information is presented, showing that prior information datasets could be incorporated at any step in the NIRS process, with the general workflow being: (i) data acquisition, (ii) pre-processing, (iii) forward model, (iv) inversion/reconstruction, (v) post-processing, and (vi) interpretation/diagnosis. Most of the development in NIRS has used ad hoc or empirical implementations of prior information such as pre-measured absorber or fluorophore spectra, or tissue shapes as estimated by additional imaging tools. A comprehensive analysis would examine what prior information maximizes the accuracy in recovery and value for medical diagnosis, when implemented at separate stages of the NIRS sequence. Individual applications of prior information can show increases in accuracy or improved ability to estimate biochemical features of tissue, while other approaches may not. Most beneficial inclusion of prior information has been in the inversion/reconstruction process, because it solves the mathematical intractability. However, it is not clear that this is always the most beneficial stage.

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Section: Prior Information: Biophysical Models (A) Biophysical Modelsmentioning

confidence: 99%

Implicit and explicit prior information in near-infrared spectral imaging: accuracy, quantification and diagnostic value

Pogue

Davis

Leblond

et al. 2011

Phil. Trans. R. Soc. A.

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show abstract

“…Concurrent fluorescence lifetime and intensity imaging indicate that internalization of HerGa is realized within approximately 40 min, during which the fluorescence lifetime of HerGa decreases, consistent with our previous observations. 22 Altogether, these results indicate that the light irradiation at the longer time points after HerGa treatment provides more enhanced light-induced cytotoxicity of HerGa.…”

Section: Discussionmentioning

confidence: 70%

“…5(b)], suggesting that photoexcitation of HerGa may be implemented in vivo. Whereas the optimal wavelength for breast cancer phototreatment is reported to be 730 nm, 22 the wavelength used here still lies partially within the red/NIR window (626 to 1316 nm) for breast tissue. Additionally, HerGa can be excited by fs pulsed light at 780 nm through the two-photon absorption process as shown in Fig.…”

Section: Discussionmentioning

confidence: 96%

Investigating photoexcitation-induced mitochondrial damage by chemotherapeutic corroles using multimode optical imaging

et al. 2012

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Abstract. We recently reported that a targeted, brightly fluorescent gallium corrole (HerGa) is highly effective for breast tumor detection and treatment. Unlike structurally similar porphryins, HerGa exhibits tumor-targeted toxicity without the need for photoexcitation. We have now examined whether photoexcitation further modulates HerGa toxicity, using multimode optical imaging of live cells, including two-photon excited fluorescence, differential interference contrast (DIC), spectral, and lifetime imaging. Using two-photon excited fluorescence imaging, we observed that light at specific wavelengths augments the HerGa-mediated mitochondrial membrane potential disruption of breast cancer cells in situ. In addition, DIC, spectral, and fluorescence lifetime imaging enabled us to both validate cell damage by HerGa photoexcitation and investigate HerGa internalization, thus allowing optimization of light dose and timing. Our demonstration of HerGa phototoxicity opens the way for development of new methods of cancer intervention using tumor-targeted corroles.

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“…Both gas inhalation/breath-holding [36,37] and external mechanical stimuli [38][39][40][41][42][43][44][45][46] have been proposed to develop novel imaging biomarkers of breast cancer. In particular, our group has obtained promising initial results by dynamically imaging the breast tissue response to fractional mammographic compression [47,48].Tissue viscoelastic relaxation during the compression period leads to a slow reduction in the compression force and reveals biomechanical and metabolic differences between normal and lesion tissue.…”

Section: Introductionmentioning

confidence: 99%

Normalization of compression-induced hemodynamics in patients responding to neoadjuvant chemotherapy monitored by dynamic tomographic optical breast imaging (DTOBI)

Sajjadi¹,

Isakoff²,

Deng³

et al. 2017

Biomed. Opt. Express

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Abstract:We characterize novel breast cancer imaging biomarkers for monitoring neoadjuvant chemotherapy (NACT) and predicting outcome. Specifically, we recruited 30 patients for a pilot study in which NACT patients were imaged using dynamic tomographic optical breast imaging (DTOBI) to quantify the hemodynamic changes due to partial mammographic compression. DTOBI scans were obtained pre-treatment (referred to as day 0), as well as 7 and 30 days into therapy on female patients undergoing NACT. We present data for the 13 patients who participated in both day 0 and 7 measurements and had evaluable data, of which 7 also returned for day 30 measurements. We acquired optical images over 2 minutes following 4-8 lbs (18-36 N) of compression. The timecourses of tissue-volume averaged total hemoglobin (HbT), as well as hemoglobin oxygen saturation (SO 2 ) in the tumor vs. surrounding tissues were compared. Outcome prediction metrics based on the differential behavior in tumor vs. normal areas for responders (>50% reduction in maximum diameter) vs. non-responders were analyzed for statistical significance. At baseline, all patients exhibit an initial decrease followed by delayed recovery in HbT, and SO 2 in the tumor area, in contrast to almost immediate recovery in surrounding tissue. At day 7 and 30, this contrast is maintained in non-responders; however, in responders, the contrast in hemodynamic time-courses between tumor and normal tissue starts decreasing at day 7 and substantially disappears at day 30. At day 30 into NACT, responding tumors demonstrate "normalization" of compression induced hemodynamics vs. surrounding normal tissue whereas non-responding tumors did not. This data suggests that DTOBI imaging biomarkers, which are governed by the interplay between tissue biomechanics and oxygen metabolism, may be suitable for guiding NACT by offering early predictions of treatment outcome. Yaffe, and G. J. Czarnota, "Evaluation of neoadjuvant chemotherapy response in women with locally advanced breast cancer using ultrasound elastography," Transl. Oncol. 6(1), 17-24 (2013).

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Simulation Study of Breast Tissue Hemodynamics During Pressure Perturbation

Cited by 16 publications

References 13 publications

Implicit and explicit prior information in near-infrared spectral imaging: accuracy, quantification and diagnostic value

Implicit and explicit prior information in near-infrared spectral imaging: accuracy, quantification and diagnostic value

Investigating photoexcitation-induced mitochondrial damage by chemotherapeutic corroles using multimode optical imaging

Normalization of compression-induced hemodynamics in patients responding to neoadjuvant chemotherapy monitored by dynamic tomographic optical breast imaging (DTOBI)

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