Simulation study of cone beam CT for visualizing cell clusters in breast biopsies

Laamanen, Curtis; LeClair, Robert J.

doi:10.1117/12.2007982

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“…The application of CBCT for the visualization of cell clusters in breast biopsies was presented at SPIE Medical Imaging 2013: Physics of Medical Imaging. 61 Results were interesting, yet the finite focal spot size, which leads to geometric blur, was not evaluated.…”

Section: Discussionmentioning

confidence: 99%

Model predictions for the wide-angle x-ray scatter signals of healthy and malignant breast duct biopsies

et al. 2015

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Abstract. Wide-angle x-ray scatter (WAXS) could potentially be used to diagnose ductal carcinoma in situ (DCIS) in breast biopsies. The regions of interest were assumed to consist of fibroglandular tissue and epithelial cells and the model assumed that biopsies with DCIS would have a higher concentration of the latter. The scattered number of photons from a 2-mm diameter column of tissue was simulated using a 110-kV beam and selectively added in terms of momentum transfer. For a 1-min exposure, specificities and sensitivities of unity were obtained for biopsies 2-to 20-mm thick. The impact of sample and tumor cell layer thicknesses was studied. For example, a biopsy erroneously estimated to be 8 mm would be correctly diagnosed if its actual thickness was between 7.3 and 8.7 mm. An 8-mm thick malignant biopsy can be correctly diagnosed provided the malignant cell layer thickness is >0.96 mm. WAXS methods could become a diagnostic tool for DCIS within breast biopsies. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Section: Discussionmentioning

confidence: 99%