Simulation study on acoustic streaming and convective cooling in blood vessels during a high-intensity focused ultrasound thermal ablation

Solovchuk, Maxim; Sheu, Tony W. H.; Lin, Win-Li; Kuo, I.Y.; Thiriet, Marc

doi:10.1016/j.ijheatmasstransfer.2011.09.023

Cited by 46 publications

(41 citation statements)

References 22 publications

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“…However, the temperature in the vein (e.g., points b, c, and d) increases more slowly than that in the tissue (e.g., points e and f) due to the lower attenuation coefficient in the vein, which demonstrates an obvious "cooling" effect of blood flow. 20 Due to the parabolic flow setting inside the vein, the lowest temperature rise is observed along the central line of the vein (point c). Since the tissue thickness above the vein (0.5 mm) is thinner than that under the vein (1.0 mm), the heat deposited in the above tissue (point a) dissipates more easily into the surrounding water, resulting in higher temperature elevations achieved in the tissue under the vein (points e and f).…”

Section: -mentioning

confidence: 98%

Controllable in vivo hyperthermia effect induced by pulsed high intensity focused ultrasound with low duty cycles

Hwang

Chen

et al. 2012

Appl. Phys. Lett.

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Section: -mentioning

confidence: 98%

Controllable in vivo hyperthermia effect induced by pulsed high intensity focused ultrasound with low duty cycles

Hwang

Chen

et al. 2012

Appl. Phys. Lett.

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“…The value of TD required for a total necrosis ranges from 25 to 240 min in biological tissues [13,17,18]. According to this relation, thermal dose resulting from heating the tissue to 43°C for 240 min is equivalent to that achieved by heating it to 56°C for 1 s.…”

Section: Energy Equation For Tissue Heatingmentioning

confidence: 99%

“…In this case, a large portion of the deposited ultrasound energy was carried away by convective cooling. Recently, a three-dimensional (3D) model to determine the influence of blood flow on the temperature distribution was presented [12,13]. To get the velocity distribution for a real blood vessel geometry, nonlinear hemodynamic equations were used.…”

Section: Introductionmentioning

confidence: 99%

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Image-based computational model for focused ultrasound ablation of liver tumor

Solovchuk

Sheu

Thiriet³

2014

J Comput Surg

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High-intensity focused ultrasound (HIFU) is a rapidly developing medical technology that allows non-invasive thermal ablation of tumors. Thermal treatment of liver tumor, which is one of the most common malignancies worldwide, is problematic because large blood vessels act as a heat sink. Convective cooling protects the cancer cells from thermal destruction and decreases the necrosed volume. A major objective of the method development is to achieve a virtually complete necrosis of tumors close to major blood vessels and to avoid blood vessel damage and, hence, the needed treatment planning. The present study is aimed at predicting liver tumor temperature during HIFU thermal ablation in a patient-specific liver geometry. The model comprises the nonlinear Westervelt equation and bioheat equations in the liver and blood vessels. The nonlinear hemodynamic equations are also taken into account with the convected cooling and acoustic streaming effects being taken into account. We found from this three-dimensional three-field coupling study that in large blood vessels, both convective cooling and acoustic streaming may change the temperature considerably near the blood vessel. More precisely, acoustic streaming velocity magnitude can be several times larger than the blood vessel velocity. The results presented in the current work can be further used to construct a surgical planning platform.

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“…Focused ultrasound treatment of liver tumor is problematic, because large blood vessels (hepatic arteries and portal veins) act as a heat sink [2]. Convective cooling can reduce the necrosed volume and tumor can regenerate [3].…”

Section: Introductionmentioning

confidence: 99%

Effects of acoustic nonlinearity and blood flow cooling during HIFU treatment

Solovchuk

Sheu

Thiriet

2012

AIP Conference Proceedings

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International audienceThe present study is aimed at predicting liver tumor temperature during a high-intensity focused ultrasound (HIFU) thermal ablation in a patient-specific liver geometry. The model comprises the nonlinear Westervelt equation and bioheat equations in liver and blood vessel. The nonlinear hemodynamic equations are also taken into account with the convected cooling and acoustic streaming effects being taken into account. We found from this three-dimensional three-field coupling study that in large blood vessel both convective cooling and acoustic streaming can change the temperature near blood vessel. Acoustic streaming velocity magnitude can be 4-5 times larger than the blood vessel velocity. Nonlinear wave propagation effects lead to the enhanced heating in the focal area and help to ablate tumor close to the blood vessel wall

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Simulation study on acoustic streaming and convective cooling in blood vessels during a high-intensity focused ultrasound thermal ablation

Cited by 46 publications

References 22 publications

Controllable in vivo hyperthermia effect induced by pulsed high intensity focused ultrasound with low duty cycles

Controllable in vivo hyperthermia effect induced by pulsed high intensity focused ultrasound with low duty cycles

Image-based computational model for focused ultrasound ablation of liver tumor

Effects of acoustic nonlinearity and blood flow cooling during HIFU treatment

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