Simulations of surface acoustic wave interactions on a sessile droplet using a three-dimensional multiphase lattice Boltzmann model

Burnside, Stephen B.; Pasieczynski, Kamil; Zarareh, Amin; Mehmood, Mubbashar; Fu, Yong Qing; Chen, Baixin

doi:10.1103/physreve.104.045301

Cited by 10 publications

(7 citation statements)

References 60 publications

(83 reference statements)

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“…At low capillary numbers, surface tension forces dominate, and the droplet remains spherical [ 95 ]. This is confirmed by Burnside et al’s simulation [ 67 ] where droplets resist deformation due to SAWs at high surface tension and maintain a spherical shape. Decreasing surface tension allows the droplet to deform more along the Rayleigh angle, resulting in longer jetting.…”

Section: Influencing Factors Of Surface Acoustic Wave Ejectionsupporting

confidence: 70%

See 1 more Smart Citation

A Comprehensive Review of Surface Acoustic Wave-Enabled Acoustic Droplet Ejection Technology and Its Applications

Ning,

Lei,

et al. 2023

Micromachines

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This review focuses on the development of surface acoustic wave-enabled acoustic drop ejection (SAW-ADE) technology, which utilizes surface acoustic waves to eject droplets from liquids without touching the sample. The technology offers advantages such as high throughput, high precision, non-contact, and integration with automated systems while saving samples and reagents. The article first provides an overview of the SAW-ADE technology, including its basic theory, simulation verification, and comparison with other types of acoustic drop ejection technology. The influencing factors of SAW-ADE technology are classified into four categories: fluid properties, device configuration, presence of channels or chambers, and driving signals. The influencing factors discussed in detail from various aspects, such as the volume, viscosity, and surface tension of the liquid; the type of substrate material, interdigital transducers, and the driving waveform; sessile droplets and fluid in channels/chambers; and the power, frequency, and modulation of the input signal. The ejection performance of droplets is influenced by various factors, and their optimization can be achieved by taking into account all of the above factors and designing appropriate configurations. Additionally, the article briefly introduces the application scenarios of SAW-ADE technology in bioprinters and chemical analyses and provides prospects for future development. The article contributes to the field of microfluidics and lab-on-a-chip technology and may help researchers to design and optimize SAW-ADE systems for specific applications.

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Section: Influencing Factors Of Surface Acoustic Wave Ejectionsupporting

confidence: 70%

“…( d – e ) A comparison between experimental and 3D LBM simulation of droplet jetting agitated by SAW. Reprinted from Burnside et al [ 67 ].…”

Section: Figurementioning

confidence: 99%

A Comprehensive Review of Surface Acoustic Wave-Enabled Acoustic Droplet Ejection Technology and Its Applications

Ning,

Lei,

et al. 2023

Micromachines

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“…In addition, the instability between the droplet and disc can induce pronounced precession of the disc, limiting the rotation speed. Therefore, there exists some optimal droplet volume corresponding to discs of various sizes to minimize precession and enable maximum centrifuge speeds ( 59 , 71 , 72 ). The viscosity of the liquid droplet is also an important consideration here.…”

Section: Resultsmentioning

confidence: 99%

Acoustic separation and concentration of exosomes for nucleotide detection: ASCENDx

Naquin,

Canning,

et al. 2024

Sci. Adv.

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Efficient isolation and analysis of exosomal biomarkers hold transformative potential in biomedical applications. However, current methods are prone to contamination and require costly consumables, expensive equipment, and skilled personnel. Here, we introduce an innovative spaceship-like disc that allows Acoustic Separation and Concentration of Exosomes and Nucleotide Detection: ASCENDx. We created ASCENDx to use acoustically driven disc rotation on a spinning droplet to generate swift separation and concentration of exosomes from patient plasma samples. Integrated plasmonic nanostars on the ASCENDx disc enable label-free detection of enriched exosomes via surface-enhanced Raman scattering. Direct detection of circulating exosomal microRNA biomarkers from patient plasma samples by the ASCENDx platform facilitated a diagnostic assay for colorectal cancer with 95.8% sensitivity and 100% specificity. ASCENDx overcomes existing limitations in exosome-based molecular diagnostics and holds a powerful position for future biomedical research, precision medicine, and point-of-care medical diagnostics.

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“…When the droplet is placed in the propagation path of the TSAW, the acoustic energy can be radiated into the droplet to create a sufficiently large acoustic pressure gradient within it [12] . As a result, the droplet can be moved in the same direction as that in which the wave is propagating [13][14][15] .…”

Section: Introductionmentioning

confidence: 99%

Velocity and Direction Adjustment of Actuated Droplets Using the Standing Wave Ratio of Surface Acoustic Waves (SAW)

Dong

Sui

et al. 2023

IEEE/ASME Trans. Mechatron.

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Droplet actuation using Surface Acoustic Wave (SAW) technology has recently been widely employed in 'lab on a chip' applications. In this paper, SAWs generated by Inter-Digital Transducers (IDTs) were used to actuate micro-droplets, where their velocity and direction could be adjusted by changing only the excitation phase shift, θ, of the voltage applied to the two IDTs. Specifically, an analytical expression for the acoustic Standing Wave Ratio (SWR), operating in the Exciter-Exciter mode, has been derived by the authors, and given as a function of θ and the spatial phase difference. It can be seen from the expression that the directions of the Traveling Surface Acoustic Waves (TSAWs) will be opposite to each other, in the range of θ given by (0, ) and (, 2), and the component of the TSAWs can be adjusted by changing θ in each direction. Following the theoretical analysis discussed here, the IDTs fabricated on a LiNbO3 substrate have been excited to generate a mixture of TSAWs and Standing Surface Acoustic Waves (SSAWs). A series of experiments was carried out to control the velocity and direction of the actuated droplets, by changing only θ. In addition, an experiment performed to compare the techniques shows that the upper limit of the velocity of the actuated droplets can be significantly increased using the Exciter-Exciter mode, showing that it has the potential to be an alternative method to the routine Exciter-Absorber mode.

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Simulations of surface acoustic wave interactions on a sessile droplet using a three-dimensional multiphase lattice Boltzmann model

Abstract: Baixin (2021) Simulations of surface acoustic wave interactions on a sessile droplet using a three-dimensional multiphase lattice Boltzmann model. Physical Review E.

Cited by 10 publications

References 60 publications

A Comprehensive Review of Surface Acoustic Wave-Enabled Acoustic Droplet Ejection Technology and Its Applications

A Comprehensive Review of Surface Acoustic Wave-Enabled Acoustic Droplet Ejection Technology and Its Applications

Acoustic separation and concentration of exosomes for nucleotide detection: ASCENDx

Velocity and Direction Adjustment of Actuated Droplets Using the Standing Wave Ratio of Surface Acoustic Waves (SAW)

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