Simultaneous administration of oral rhesus-human reassortant tetravalent (RRV-TV) rotavirus vaccine and oral poliovirus vaccine (OPV) in Thai infants

Comparison of 2 Different Regimens for Reactogenicity, Safety, and Immunogenicity of the Live Attenuated Oral Rotavirus Vaccine RIX4414 Coadministered with Oral Polio Vaccine in South African Infants

“…These findings were consistent with previous studies of RIX4414 [8,9] and animal-based rotavirus vaccines [27][28][29]. In the placebo group, wild-type rotavirus was not detected at any of the predetermined times, confirming low circulation of rotavirus during the study period.…”

“…In this earlier study, in which RIX4414 was administered either concomitantly with OPV or with inactivated polio vaccine, it was shown that OPV interfered with the first-dose RIX4414 response, although this low immune response to RIX4414 was overcome by the second vaccination with RIX4414 and OPV. This phenomenon of OPV interference with the rotavirus vaccine response at the first dose has been observed with other rotavirus vaccine candidates [27][28][29].…”

Concomitant Use of the Oral Pentavalent Human-Bovine Reassortant Rotavirus Vaccine and Oral Poliovirus Vaccine

“…Historically, immune responses to other rotavirus vaccines (eg, bovine RIT 4237 vaccine, rhesus rotavirus tetravalent vaccine) were suppressed to varying degrees when administered with OPV; although immune responses to OPV were not affected. [3][4][5][6][7] …”

“…Historically, immune responses to other rotavirus vaccines (eg, bovine RIT 4237 vaccine, rhesus rotavirus tetravalent vaccine) were suppressed to varying degrees when administered with OPV; although immune responses to OPV were not affected. [3][4][5][6][7] The present study evaluated the safety and immunogenicity of PRV and OPV when used concomitantly in healthy Latin American infants at 2, 4, and 6 months of age. The study tested the noninferiority of concomitant administration of PRV and OPV versus staggered administration (1) in terms of the seroprotection rate for poliovirus types 1, 2, and 3 and (2) in terms of the geometric mean titer (GMT) of antirotavirus IgA-each measured 42 days after the last vaccine dose.…”

Changes in Childhood Diarrhea Incidence in Nicaragua Following 3 Years of Universal Infant Rotavirus Immunization

“…It is unclear whether the rotavirus vaccines will perform as well in the developing world, due to factors such as the distribution of rotavirus genotypes8–11, the simultaneous use of the oral polio vaccine12–14, a higher prevalence of malnutrition15–17 and breastfeeding, 18–21 and possible inadequate vaccine storage conditions. The monovalent rotavirus vaccine provided only 49% efficacy against severe rotavirus gastroenteritis in a recent clinical trial in Malawi, significantly lower than the vaccine's efficacy in upper-income countries 22,23.…”