Simultaneous Analysis of Levocetirizine Dihydrochloride, Ambroxol Hydrochloride, and Montelukast Sodium by Rp-HPLC - Pda Method

Srividya, P.; Tejaswini, M; Sravanthi, D.; Nalluri, Buchi N.

doi:10.1080/10826076.2012.725701

Cited by 7 publications

(7 citation statements)

References 1 publication

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“…The method proposed by Srividya P et al. was successfully applied and validated as per ICH guidelines [47].…”

Section: Analytical Methods Used To Estimate Montelukast Sodiummentioning

confidence: 99%

“…The authors found good linearity in the concentration range of 4-20 μg/mL for LCZ, 30-150 μg/mL for AMB, and 8-40 μg/mL for MONTE with a coefficient of correlation (r 2 ) of 0.998, 0.999, and 0.995, and percentage assay was found to be LCZ (99.1%), AMB (98.5%), and MONTE (102.5%), respectively. The method proposed by Srividya P et al was successfully applied and validated as per ICH guidelines [47].…”

Section: High-performance Liquid Chromatography (Hplc)mentioning

confidence: 99%

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An analytical review for the estimation of montelukast sodium

Anant

Saha

Dhiman

et al. 2022

Separation Science Plus

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Montelukast is a highly potent and selective receptor antagonist of cysteinyl leukotrienes (CysLT1) used in chronic asthma and vasoconstriction reduction and also used in allergies, swelling, hay fever, and shortness of breath. For the measurement of montelukast sodium in biological and pharmaceutical samples, there are different asynchronous and concurrent analytical methods, such as high‐performance thin layer chromatography, UV spectroscopy, capillary electrophoresis, high‐performance liquid chromatography, and liquid chromatography‐mass spectrometry, have been developed. The pathogenesis of asthma, mechanism of action, and various analytical methods for the detection of montelukast sodium and its combination of dosage forms and biological samples have been described in the present review. Ranjan et al. suggested the reverse phase high‐performance liquid chromatography approach for estimating montelukast in rabbit plasma and found the best limit of detection result of 1.0 ng/mL. Ezzeldin et al. developed a liquid chromatography with tandem mass spectrometry system for the simultaneous detection of combinations of montelukast, gliclazide, and nifedipine. The authors conclude that the studies described in the present manuscript will assist researchers in choosing a simple, rapid, and responsive method for the analysis of montelukast sodium and its combinations.

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“…The method proposed by Srividya P et al. was successfully applied and validated as per ICH guidelines [47].…”

Section: Analytical Methods Used To Estimate Montelukast Sodiummentioning

confidence: 99%

Section: High-performance Liquid Chromatography (Hplc)mentioning

confidence: 99%

An analytical review for the estimation of montelukast sodium

Anant

Saha

Dhiman

et al. 2022

Separation Science Plus

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“…The Literature survey revealed that this combination is not official in any Pharmacopoeia but there are several methods that have been reported to determine PCM, LEVO, PHEN and AMB as individual or in combination with other drugs, such as UV, UPLC, LC-MS, GC-MS, LC-MS/MS and HPLC with UV/PDA detection. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] For estimation of these four drugs combination, two methods are available such as RP-HPLC and UV. 23,24 Literature survey reveals that no isocratic elution method reported yet for the determination of Ambroxol hydrochloride, Levocetirizine hydrochloride, Phenylephrine hydrochloride and Paracetamol in combine Dosage form.…”

Section: Introductionmentioning

confidence: 99%

Estimation of four drugs: Ambroxol hydrochloride, Levocetirizine hydrochloride, Phenylephrine hydrochloride and Paracetamol by RP-HPLC in tablet dosage form

2020

IJPCA

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A simple, specific, precise, accurate and economic isocratic RP-HPLC method was developed for the simultaneous determination of Ambroxol hydrochloride, Levocetirizine hydrochloride, Phenylephrine hydrochloride and Paracetamol in bulk and tablet dosage form. A reverse phase Nucleosil C18 column (250 mm x 4.6 mm x 5 µm) with mobile phase consisting of Methanol: Sodium Phosphate dibasic anhydrous Buffer (65:35 V/V) having (pH of buffer 7.0 ± 0.02 adjusted with ortho phosphoric acid) was used. The flow rate was 1.0 mL/min and the effluents were monitored at 230 nm. The retention times of Paracetamol, Levocetirizine hydrochloride, Phenylephrine hydrochloride and Ambroxol hydrochloride were found to be 3.117, 4.925, 6.217 and 12.308 min. respectively. The method was validated in terms of linearity, range, specificity, accuracy, precision and robustness. The proposed method was successfully applied for the estimation of paracetamol, levocetirizine hydrochloride, phenylephrine hydrochloride and ambroxol hydrochloride in combined tablet dosage form.

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“…A literature survey reveals many techniques have been stated for the determination of LEV, GUA and AMB either alone or in combinations with other active ingredients in a multi-component tablet and liquid dosage formulation as predictable with the variation of column detector and mobile phase. Various methods like HPLC (Vasudevan M et al, 2007;Joshi S et al, 2011;Jain j et al, 2008;Prathap S et al, 2010;Mukesh M et al, 2010;Krishnaveninagappan J et al, 2008;Srividya P et al, 2013;Laura C et al, 1983;Vani R et al, 2014) HPTLC (Prasant j, 2010;Sharma E, 2012;Krunal S, 2014;Bagada H, 2013), Spectrophotometric (Kim R et al, 2011;Umadevi B et al, 2009;Nehal S, 2012;Nirav C et al, 2013;Amit P et al, 2011;Gangwal S et al, 1999) and few LC-MS (Harshal P et al, 2014;Snehal G et al, 2014;Dong X et al, 2013) methods were used for determination of drugs even in Human plasma. Therefore, the present work is aimed to build up and validate RP UPLC method for simultaneous estimation of cough syrup containing LEV, GUA, and AMB in bulk and pharmaceutical dosage forms according to ICH guidelines (ICH Q2(R1) 1996).…”

Section: Introductionmentioning

confidence: 99%

Reverse phase-UPLC method of analysis for simultaneous estimation of Levosalbutamol sulphate, Guaiphenesin and Ambroxol hydrochloride in pharmaceutical cough, cold liquid dosage forms

Balakrishnan²,

Chandrasekhar

et al. 2019

ijrps

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The three most drug combinations for cough, cold are widely used worldwide now a day. The purpose of the study was to build up an innovative RP-UPLC technique for simultaneous estimation of Levosalbutamol Sulphate (LEV), Guaiphenesin (GUA) and Ambroxol Hydrochloride (AMB) in liquid dosage forms. Chromatography was carried out on UHPLC (WATERS)_SYMMETRY® C18 4.6mm x 1000mm, 3.5µm, (Agilent - Zorbax Eclipse Plus C18 – Rapid Resolution) with an isocratic mobile phase with pH 3.0 composed of buffer, methanol and Acetonitrile (60:20:20) with a flow rate of 0.8mL/min. The detection was carried out with column temperature at 25°C using a UV detector at 276nm. Validation parameters like linearity, specificity, precision, accuracy, limit of detection (LOD), limit of quantification (LOQ), system suitability, Solutions stability and robustness were considered as affirmed in the ICH guidelines. Retention times for LEV, GUA & AMB were 1.07 min, 1.99 min & 3.55 min respectively. The assay of syrups with the relative standard deviation found to be less than 2%. The parameters values were found, and the method was found to be satisfactory. This validated UHPLC method is cost-effective, receptive and precise than other chromatographic methods.

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Simultaneous Analysis of Levocetirizine Dihydrochloride, Ambroxol Hydrochloride, and Montelukast Sodium by Rp-HPLC - Pda Method

Cited by 7 publications

References 1 publication

An analytical review for the estimation of montelukast sodium

An analytical review for the estimation of montelukast sodium

Estimation of four drugs: Ambroxol hydrochloride, Levocetirizine hydrochloride, Phenylephrine hydrochloride and Paracetamol by RP-HPLC in tablet dosage form

Reverse phase-UPLC method of analysis for simultaneous estimation of Levosalbutamol sulphate, Guaiphenesin and Ambroxol hydrochloride in pharmaceutical cough, cold liquid dosage forms

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