Simultaneous analysis of some club drugs in whole blood using solid phase extraction and gas chromatography–mass spectrometry

Simultaneous quantitation of meperidine, normeperidine, tramadol, propoxyphene and norpropoxyphene in human plasma using solid‐phase extraction and gas chromatography/mass spectrometry: Method validation and application to cardiovascular safety of therapeutic doses

“…Numerous analytical methods have been described for the quantitative determination of MEP, TRAM or dextropropoxyphene, alone or with their metabolites, in plasma samples. Gas chromatography/mass spectrometry (GC/MS) and liquid chromatography/mass spectrometry (LC/MS) are the main techniques used for most of these methods.…”

Validation of a method for simultaneous analysis of cocaine, benzoylecognine and cocaethylene in urine using gas chromatography-mass spectrometry

“…SPE is indeed a technique of greater sensitivity and specificity; its use is advantageous due to the fact it does not reque as many organic solvents as other extraction techniques, in addition to not forming emulsions during the extraction process, which interfere with the amount of analyte extracted (Moreau, Siqueira, 2016). According to Castro et al (2012), the use of SPE for detection of drugs of abuse allows a good recovery and sensitivity, thus, reducing analysis interferences.…”

Detection and Quantification of 56 New Psychoactive Substances in Whole Blood and Urine by LC–MS/MS

“…Methods covering several substance classes include fewer substances than the method presented here [47,52,58,62] or are intended for qualitative screening purposes rather than quantification [40,42,50,60,64]. More comprehensive methods have been developed by Al-Saffar et al (27 compounds, urine) [38], Paul et al (35 compounds, urine) [39] and Swortwood et al (32 substances, serum) [49].…”

“…While synthetic cannabinoid receptor agonists make up a significant part of the NPS phenomenon, readers interested in these compounds are kindly referred to the publications of our EU project partners [33][34][35][36][37]. Several methods have been published for the detection of NPS in urine [38][39][40][41][42][43][44], plasma/serum [45][46][47][48][49][50], whole blood [51][52][53], hair [54][55][56][57], oral fluid [58], nails [59], dried blood spots [60], as well as multiple matrices [61][62][63][64][65]. However, these methods often focus on only one or two substance classes or a limited number of substances [41][42][43][44][45][46][47][51][52][53][54][55]58,62,…”