2019
DOI: 10.1113/jp277691
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Simultaneous assessment of central and peripheral chemoreflex regulation of muscle sympathetic nerve activity and ventilation in healthy young men

Abstract: Key pointsr Central chemoreceptor stimulation, by hypercapnia (acidosis), and peripheral, by hypoxia plus hypercapnia, evoke reflex increases in ventilation and sympathetic outflow.r The assumption that central or peripheral chemoreceptor-mediated sympathetic activation elicited when P CO 2 increases parallels concurrent ventilatory responses is unproven.r Applying a modified rebreathing protocol that equilibrates central and peripheral chemoreceptor P CO 2 whilst clamping O 2 tension at either hypoxic or hype… Show more

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Cited by 56 publications
(76 citation statements)
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“…The main finding of Keir et al . () was that the P ETC O2 evoked an MSNA and ventilatory response at the same threshold. However, during the isoxic hyperoxic condition (which estimates the central chemoreflex) P ETC O2 evoked ventilatory and MSNA responses at a higher P ETC O2 threshold (45.6 ± 3.3 mmHg vs .…”
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confidence: 87%
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“…The main finding of Keir et al . () was that the P ETC O2 evoked an MSNA and ventilatory response at the same threshold. However, during the isoxic hyperoxic condition (which estimates the central chemoreflex) P ETC O2 evoked ventilatory and MSNA responses at a higher P ETC O2 threshold (45.6 ± 3.3 mmHg vs .…”
mentioning
confidence: 87%
“…Thus, the difference between the hypoxic and hyperoxic rebreathing tests reflects the specific peripheral chemoreflex contribution to the net response. The main finding of Keir et al (2019) was that the P ETCO2 evoked an MSNA and ventilatory response at the same threshold. However, during the isoxic hyperoxic condition (which estimates the central chemoreflex) P ETCO2 evoked ventilatory and MSNA responses at a higher P ETCO2 threshold (45.6 ± 3.3 mmHg vs. 45.0 ± 4.2 mmHg, respectively), whereas the evoked ventilatory and MSNA responses occur at a lower P ETCO2 threshold (41.2 ± 3.1 mmHg vs. 41.4 ± 3.2 mmHg, respectively) for the estimated peripheral chemoreceptors (hypoxic minus hyperoxic rebreathing tests).…”
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confidence: 97%
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