An experimental phantom study was performed to evaluate cardiac uniformity, contrast, and signal-to-noise ratio for two clinical cardiac SPECT imaging protocols: adjacent dual-head 180 and triple-head 360 scans. One head of a SPECT camera was used to acquire 180 and 360 projections with different times per step to simulate the clinical case where dual-head 180 and triple-head 360 each takes a total of 20 min. Scans were acquired with no lesion, anterior lesion, and posterior lesion in the myocardium. Maximum a posteriori reconstruction was done by an iterative coordinate descent algorithm using a quadratic convex prior. The L-curve method was used to obtain the prior strength. Some investigation was done on obtaining the L-curve and on the ways to fit the L-curve and to get the corner point. Images both with attenuation and scatter correction (ASC) and without ASC were compared. The 180 scan shows an intensity decrease in anterior apical and posterior basal regions. The 360 scan shows an intensity decrease in the posterior wall. For the anterior lesion, the 180 scan has slightly better contrast, while for the posterior lesion, the 360 scan has slightly better contrast. The difference between the 180 and 360 scans is subtle, and the comparison results depend on the lesion position and the view angle of the heart. A receiver operating characteristic study of 180 versus 360 acquisition designed based on these characterizations of contrast, uniformity, and noise will be necessary to evaluate overall performance.