:The membrane biofilm reactor (MBfR) creates a natural partnership of a membrane and biofilm, because a gas-transfer membrane delivers a gaseous substrate to the biofilm that grows on the membrane's outer wall. O2-based MBfRs (called membrane aerated biofilm reactors, or MABRs) have existed for much longer than H2-based MBfRs, but the H2-based MBfR is a versatile platform for reducing oxidized contaminants in many water-treatment settings: drinking water, ground water, wastewater, and agricultural drainage. Extensive bench-scale experimentation has proven that the H2-based MBfR can reduce many oxidized contaminant to harmless or easily removed forms: e.g., NO3 to N2, ClO4 to H2O and Cl-, SeO4 2to Se°, and trichloroethene (TCE) to ethene and Cl-. The MBfR has been tested at the pilot scale for NO3 and ClO4 and is now entering field-testing for many of the oxidized contaminants alone or in mixtures. For the MBfR to attain its full promise, several issues must be addressed by bench and field research: understanding interactions with mixtures of oxidized contaminants, treating waters with a high TDS concentration, developing modules that can be used in situ to augment pre-denitrification of wastewater, and keeping the capital costs low.