Abstract:An
easy-to-synthesize, biimidazole push–pull dye has been
designed, comprising two mutually independent analyte binding sites.
It has been found that Hg2+ coordinates with the compound
via thiophene residue and inhibits the charge-transfer (CT) process,
which transforms the yellow-colored solution colorless. On the other
hand, an unusually large bathochromic shift is observed in CT band
upon addition of Cu2+, accompanied by a change in the color
from yellow to red. A rather surprising observation is made from … Show more
“…To rationalize the ribose‐specific interaction, 1 was optimized with and without D‐ribose (1 : 2) using B3LYP/6‐31G* level of theory (Figure 5a) [29] . The energy‐minimized structure of 1 showed a nearly planar structure with two terminal pyridine units at the out of plane conformation (∼27°).…”
Easily synthesizable, carbazole-based organic nanoaggregates have been designed for selective detection of D-(À )-ribose at physiological pH. The addition of D-ribose results in a ratiometric change in fluorescence color from green to cyan (LOD: ~12 μM). The mechanistic studies indicate the presence of multipoint noncovalent interactions, such as hydrogen bonding and CH•••π interactions between D-ribose and acyl hydrazone and terminal pyridyl units of the probe molecule. However, such multipoint interactions dissociate the preformed self-assembled nanoclusters and induce change in optical response. The probe molecule was further exploited in analyzing D-ribose content in biological fluids (diluted human urine and blood serum) and oral supplements. The small standard deviation values (2-3.8 %) with nearly quantitative recovery (93.5-105.5 %) indicate the high accuracy of the presented method. Further, low-cost portable device based coated paper strips were designed for 'on-location' rapid, detection of Dribose even at remote locations.
“…To rationalize the ribose‐specific interaction, 1 was optimized with and without D‐ribose (1 : 2) using B3LYP/6‐31G* level of theory (Figure 5a) [29] . The energy‐minimized structure of 1 showed a nearly planar structure with two terminal pyridine units at the out of plane conformation (∼27°).…”
Easily synthesizable, carbazole-based organic nanoaggregates have been designed for selective detection of D-(À )-ribose at physiological pH. The addition of D-ribose results in a ratiometric change in fluorescence color from green to cyan (LOD: ~12 μM). The mechanistic studies indicate the presence of multipoint noncovalent interactions, such as hydrogen bonding and CH•••π interactions between D-ribose and acyl hydrazone and terminal pyridyl units of the probe molecule. However, such multipoint interactions dissociate the preformed self-assembled nanoclusters and induce change in optical response. The probe molecule was further exploited in analyzing D-ribose content in biological fluids (diluted human urine and blood serum) and oral supplements. The small standard deviation values (2-3.8 %) with nearly quantitative recovery (93.5-105.5 %) indicate the high accuracy of the presented method. Further, low-cost portable device based coated paper strips were designed for 'on-location' rapid, detection of Dribose even at remote locations.
“…To establish the mode of interaction of the probe with Cu 2+ and Zn 2+ , we determined the binding stoichiometries of 1 with both of these ions using Job's method (Figure b) . In both cases 1:1 interaction was observed along with significantly high binding constant values, such as 4.81 x 10 4 ± 56.3 mol −1 (For Cu 2+ ) and 1.04 x 10 5 ± 70.9 mol −1 (For Zn 2+ ) (Figure S9) .…”
Design and Synthesis of Compound Synthesis and characterization: Compound 2 was prepared according to a literature reported procedure using N-chlorosuccinimide as a reagent in glacial acetic acid. S1 Compounds 3, 4 and 5 were prepared following a reported procedure in literature. S2 Compound 7 was synthesized by modified Ullmann coupling using palladium acetate as a catalyst. S3 Compound 8 and 9 were synthesized according to a literature reported procedure. S4
“…BODIPY derivatives are known as excellent chromophore photochemical and thermal stability and salen is an excellent ligand system due to their effective coordination behavior with electron-deficient Lewis-acid (metal center). [52,53] Sensor 6 [54] was designed by the combination of the mentioned two advantageous segments for the detection of Hg Biimidazole push-pull dye, sensor 7 [55] coordinates with Hg 2+ through the thiophene unit ( Figure 4) and stopped the charge transfer process to change the color to colorless from yellow in CH 3 CN-water (1:1) mixture with a LOD of 32.8 ppb. Combination of thiosemicarbazone and 4-(diphenylamino) benzaldehyde, sensor 8 [56] can detect Hg 2+ in DMSO/Tris-Hcl (8:2, v/v, pH=7.0) medium.…”
Section: Heteroatom Based Ligand Containing Small Moleculesmentioning
Exposure of Hg(II) and As(III) leads to several physiological problems to humans, such as liver damage, kidney damage, lung cancer, skin cancer, motion disorder, brain damage, etc. To monitor and...
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