Simultaneous Detection of Ochratoxin A and Aflatoxin B1 Based on Stable Tuning Fork-shaped DNA Fluorescent Aptasensor

Wang, Mengyao; Lv, Zeping; Liu, Yong; Wei, Min

doi:10.1007/s10895-024-03668-y

J Fluoresc

2024

DOI: 10.1007/s10895-024-03668-y

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Simultaneous Detection of Ochratoxin A and Aflatoxin B1 Based on Stable Tuning Fork-shaped DNA Fluorescent Aptasensor

Mengyao Wang,

Zeping Lv,

Yong Liu

et al.

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Cited by 3 publications

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MNPs-aptazymes-PtNPs molecular motor biosensor mediated by circular cleavage reactions for the ultrasensitive detection of aflatoxin B1 in real samples

He,

Liu,

Han

et al. 2024

Microchemical Journal

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MNPs-aptazymes-PtNPs molecular motor biosensor mediated by circular cleavage reactions for the ultrasensitive detection of aflatoxin B1 in real samples

He,

Liu,

Han

et al. 2024

Microchemical Journal

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Dual-ratiometric fluorescent aptasensor based on gold nanoclusters and dual-amplification strategy for simultaneous detection of ochratoxin A and aflatoxin B1

Wang,

Xiao,

Zhao

et al. 2025

Sensors and Actuators B: Chemical

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Ultrasensitive Imaging Assay of Multiple Mycotoxins Using Cobalt DNA–Inorganic Hybrid Superstructure with High Chemiluminescence Catalytic Property

Zhang,

Yang,

Zhang

et al. 2024

Anal. Chem.

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A multiplex assay of mycotoxins in food and medicine is urgently needed and challenging due to synergistic hazards of trace mycotoxins and a lack of sensitive and user-friendly detection approaches. Herein, a cobalt DNA−inorganic hybrid superstructure (Co@DS) was developed through isothermal rolling circle amplification (RCA) for an ultrasensitive chemiluminescence (CL) imaging assay of multiple mycotoxins. Cobalt ions were enriched in the RCA product, endowing the Co@DS with a high CL catalytic property. Experimental studies elucidated the formation and CL catalytic mechanism of Co@DS. Co@DS was facilely integrated with biotinylated DNA to function as a universal platform and combined with a disposable immunosensor array chip. After a competitive immunoassay and biotin−avidin recognition, the CL signals of luminol and hydrogen peroxide, catalyzed by Co@DS captured on each testing zone of the array chip, were imaged simultaneously. Target mycotoxins can be quantitated by CL intensities. To validate the concept, the CL imaging approach was employed for joint determination of aflatoxin B 1 , ochratoxins A, and zearalenone. Under optimal conditions, it showed advantages including simple sample pretreatment, acceptable throughput, high accuracy, minimal sample consumption, broad linear ranges, and detection limits as low as 0.75, 0.62, and 0.61 pg mL −1 , respectively. Furthermore, the approach was applied in analyzing real coix seed samples, showcasing excellent performance in effectively distinguishing qualified and contaminated medicine, revealing the great potential in managing the complex issue of mycotoxins cocontamination in food and medicine.

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Simultaneous Detection of Ochratoxin A and Aflatoxin B1 Based on Stable Tuning Fork-shaped DNA Fluorescent Aptasensor

Cited by 3 publications

References 44 publications

MNPs-aptazymes-PtNPs molecular motor biosensor mediated by circular cleavage reactions for the ultrasensitive detection of aflatoxin B1 in real samples

MNPs-aptazymes-PtNPs molecular motor biosensor mediated by circular cleavage reactions for the ultrasensitive detection of aflatoxin B1 in real samples

Dual-ratiometric fluorescent aptasensor based on gold nanoclusters and dual-amplification strategy for simultaneous detection of ochratoxin A and aflatoxin B1

Ultrasensitive Imaging Assay of Multiple Mycotoxins Using Cobalt DNA–Inorganic Hybrid Superstructure with High Chemiluminescence Catalytic Property

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