Simultaneous determination in hair of multiclass drugs of abuse (including THC) by ultra-high performance liquid chromatography–tandem mass spectrometry

Corcia, D. Di; D'Urso, F.; Gerace, Enrico; Salomone, Alberto; Vincenti, Marco

doi:10.1016/j.jchromb.2012.05.003

Cited by 68 publications

(43 citation statements)

References 21 publications

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“…Considering the study group, this phenomenon can be explained by diffusion and especially the abused substance incorporation via sweat and sebum secretions [13,14].…”

Section: Resultsmentioning

confidence: 98%

Validity of Substances of Abuse Detection in Hair by Biochips Array Technology

Ragab¹,

Al-Mazroua²,

El-Harouny³

et al. 2018

J Alcohol Drug Depend

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Using hair as a biological specimen to analyze drug abuse has been receiving elevated attention during last years because of flexibility of collection procedure and because hair does not autolysis like other body fluids or tissues. Hair testing provides a broad-spectrum detection window after drug exposure than urine testing. Hair analysis has specific criteria that it provides a way of obtaining information that cannot be acquired by other commonly used forensic toxicology analytical procedures, such as blood or urine analysis. In the hair matrix, many xenobiotics are trapped permanently, in disparity to the situation with blood or urine where they are only identifiable for a few hours or days. Subsequently substance of abuse detection by hair analysis should be the target procedure in the clinical and forensic toxicology aspect when the evaluation of repeated or chronic exposure to a drug is indicated, e.g. in the case of pre-employment/workplace testing, criminal affairs or a driving license restoration. In the current study, seventy cases of the application of hair analyses using this technique for the determination of substances of abuse (opiates, cannabis, amphetamine, barbiturate, benzodiazepines, and cocaine) are investigated. Analytical toxicology procedure for detection of substance of abuse is critical important: Biochips array technology that confirmed with GC/MS has proved to be a highly sensitive and specific technique for the detection of substances of abuse at very low concentrations in hair except for cannabis.

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“…Considering the study group, this phenomenon can be explained by diffusion and especially the abused substance incorporation via sweat and sebum secretions [13,14].…”

Section: Resultsmentioning

confidence: 98%

Validity of Substances of Abuse Detection in Hair by Biochips Array Technology

Ragab¹,

Al-Mazroua²,

El-Harouny³

et al. 2018

J Alcohol Drug Depend

View full text Add to dashboard Cite

show abstract

“…Di Corcia et al proposed a simple sample 274 extraction and direct injection into a UHPLC-MS/MS system to avoid solid-phase and liquid-liquid 275 extraction and to achieve fast and simultaneous detection of the most common drugs of abuse, 276 including THC, in hair samples (Di Corcia et al, 2012) . Lendoiro et al developed (Lendoiro et al, 2012).…”

mentioning

confidence: 99%

Application of mass spectrometry to hair analysis for forensic toxicological investigations

Vincenti

Salomone²,

Gerace³

et al. 2012

Mass Spectrometry Reviews

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The increasing role of hair analysis in forensic toxicological investigations principally owes to recent improvements of mass spectrometric instrumentation. Research achievements during the last six years in this distinctive application area of analytical toxicology are reviewed. The earlier state of the art of hair analysis was comprehensively covered by a dedicated book (Kintz, 2007a), that represents key reference of the present overview. Whereas the traditional organization of analytical methods in forensic toxicology divided target substances into quite homogeneous groups of drugs, with similar structures and chemical properties, the current approach often takes advantage of the rapid expansion of multiclass and multiresidue analytical procedures; the latter is made possible by the fast operation and extreme sensitivity of modern mass spectrometers. This change in the strategy of toxicological analysis is reflected in the presentation of the recent literature material, which is mostly based on a fit-for-purpose logic. Thus, general screening of unknown substances is applied in diverse forensic contexts than drugs of abuse testing, and different instrumentation (triple quadrupoles, time-of-flight analyzers, linear and orbital traps) is utilized to optimally cope with the scope. Other key issues of modern toxicology, such as cost reduction and high sample throughput, are discussed with reference to procedural and instrumental alternatives.

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“…After the introduction of DESI, many ambient ionization techniques have been developed, which have been classified into seven categories by Monge et al [50] based on their desorption/ionization mechanism, although other subdivisions have also been proposed [51][52][53] :…”

Section: Ambient Mass Spectrometrymentioning

confidence: 99%

“…[68] The general m/z range covered by DART starts at around m/z 50 and goes up to m/z 1,200. [51] The analysis of high molecular weight molecules, even above m/z 5,000, was demonstrated using ionic liquids. [69] The limiting factor in DART ionization is the ability of an analyte to (thermally) desorb from the sample, without thermal degradation.…”

Section: Applications Of Dartmentioning

confidence: 99%

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Improved forensic hair evidence for drugs of abuse by mass spectrometry

Duvivier

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Simultaneous determination in hair of multiclass drugs of abuse (including THC) by ultra-high performance liquid chromatography–tandem mass spectrometry

Cited by 68 publications

References 21 publications

Validity of Substances of Abuse Detection in Hair by Biochips Array Technology

Validity of Substances of Abuse Detection in Hair by Biochips Array Technology

Application of mass spectrometry to hair analysis for forensic toxicological investigations

Improved forensic hair evidence for drugs of abuse by mass spectrometry

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