Simultaneous determination of 13 sulfonamides at trace levels in soil by modified QuEChERS with HPLC-MS/MS

Liu, Chen; Sun, YouMin; Zhou, ZhaoTing; Fan, Jing; Yuan, JinPeng

doi:10.1039/d3ay01564e

Anal. Methods

2024

DOI: 10.1039/d3ay01564e

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Simultaneous determination of 13 sulfonamides at trace levels in soil by modified QuEChERS with HPLC-MS/MS

Chen Liu,

YouMin Sun,

ZhaoTing Zhou

et al.

Abstract: Schematic of the main steps for QuEChERS.

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Cited by 2 publications

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“…Due to the contamination of MS parts (capillary, sampling cone, even quadrupole) and ion suppression caused by salts, these samples are unable to be directly analyzed by MS. − Researchers have developed many pretreatment methods to solve these problems and realize the MS analysis of drugs in salt-containing matrices. Solid-phase extraction (SPE) and QuEChER combined with MS are often used to detect antibiotics and sulfonamides residing in seawater or soil. − However, these methods are cumbersome and time-consuming, and some trace analytes may be degraded through pretreatments.…”

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confidence: 99%

Crystallization and Solvent Evaporation Ionization Mass Spectrometry (CSEI-MS) for Rapid Detection of Drugs in Complex Matrices

Chen,

Li,

Luo

et al. 2024

Anal. Chem.

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Illegal addition of drugs is common but seriously threatens public health safety. Conventional mass spectrometry methods are difficult to realize direct analysis of drugs existing in some complex matrices such as seawater or soil due to the ion suppression effect and contamination to MS parts caused by nonvolatile salts. In this work, a novel crystallization and solvent evaporation ionization mass spectrometry (CSEI-MS) method was constructed and developed to achieve rapid desalting detection. CSEI only consists of a heated plate and a nebulizer and exhibits excellent desalting performance, enabling direct analysis of six drugs dissolved in eight kinds of salt solutions (up to 200 mmol/L) and three complex salty matrices. Under optimized conditions, CSEI-MS presents high sensitivity, accuracy, linearity, and intraday and interday precision. Finally, this method is applied to the quantitative analysis of drugs in seawater, hand cream, and soil. Furthermore, the highly sensitive detection of CSEI-MS is demonstrated to remain even if the detection processes are conducted within 5 s via common commercial tools.

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confidence: 99%

Crystallization and Solvent Evaporation Ionization Mass Spectrometry (CSEI-MS) for Rapid Detection of Drugs in Complex Matrices

Chen,

Li,

Luo

et al. 2024

Anal. Chem.

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Chiral method validation and stereoselective degradation of profoxydim isomers in paddy soil

Cervantes-Díaz,

Mateo-Miranda,

Alonso-Prados

et al. 2024

Environ Sci Pollut Res

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The herbicide profoxydim, which is chiral in nature, is commonly used for weed control in rice. However, traditional achiral analysis treats profoxydim isomers as a single compound, providing only partial and inaccuracy information assuming identical behavior for the four isomers. To address this issue, a sensitive and straightforward chiral analytical method was developed using QuEChERS and chiral HPLC–MS/MS to determine the residues of all four stereoisomers of profoxydim in soil. The method was validated and found to have good accuracy and precision, with recoveries ranging from 88.27 to 104.93% for dry soil and from 98.25 to 106.53% for soaked soil, with RSD values lower than 11.14%. The limit of detection for the profoxydim isomers was 7.6 µg/kg, and the limit of quantification was 25.0 µg/kg. Furthermore, the proposed method was employed for the first time to investigate the individual degradation of novel isolated stereoisomers of profoxydim in soil and the kinetics and evolution of the generated degradation products (DPs). The degradation of the four stereoisomers followed first-order kinetics and was found to be stereoselective, with isomers 1 and 4 preferentially degrading with half-lives of 14.7 and 15.6 h respectively. The profoxydim enantiomers remained configurationally stable without any interconversion throughout the experiment. The findings of this study provide a robust scientific basis for improving profoxydim risk assessment and highlight the need to characterize chiral agrochemical isomers to better understand their environmental distribution and fate.

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Simultaneous determination of 13 sulfonamides at trace levels in soil by modified QuEChERS with HPLC-MS/MS

Abstract: Schematic of the main steps for QuEChERS.

Cited by 2 publications

References 37 publications

Crystallization and Solvent Evaporation Ionization Mass Spectrometry (CSEI-MS) for Rapid Detection of Drugs in Complex Matrices

Crystallization and Solvent Evaporation Ionization Mass Spectrometry (CSEI-MS) for Rapid Detection of Drugs in Complex Matrices

Chiral method validation and stereoselective degradation of profoxydim isomers in paddy soil

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