Simultaneous determination of 5′-deoxy-5-fluorouridine, 5-fluorouracil and 5,6-dihydro-5-fluorouracil in plasma by gas chromatography-mass spectrometry

Zambonin, Carlo; Guerrieri, Antonio; Palmisano, Francesco

doi:10.1016/0003-2670(96)00118-3

Cited by 10 publications

(2 citation statements)

References 29 publications

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“…Occupational environmental samples (air, glove) were analysed with an SPE cartridge (Isolute ENVþ). LLE methods were used for the extraction of 5-fluorouracil from human or rat plasma and urine [29][30][31][32]. The extraction was followed either by HPLC and UV detection [28,[33][34][35] or by GC-MS where appropriate derivatization increases the sensitivity [31,36,37].…”

Section: Introductionmentioning

confidence: 99%

Trace determination of tamoxifen and 5-fluorouracil in hospital and urban wastewaters

Tauxe-Wuersch

Alencastro

Grandjean

et al. 2006

International Journal of Environmental Analytical Chemistry

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Section: Introductionmentioning

confidence: 99%

Trace determination of tamoxifen and 5-fluorouracil in hospital and urban wastewaters

Tauxe-Wuersch

Alencastro

Grandjean

et al. 2006

International Journal of Environmental Analytical Chemistry

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“…Este composto terapêutico é utilizado clinicamente em casos de câncer do trato gastrointestinal, pulmão, do aparelho genital feminino e em terapia de melanomas como um complemento terapêutico ou como tratamento primário (Zambonin et al, 1996;Ryan et al, 1988).…”

Section: -Fluorouracilunclassified

Preparação e caracterização de lipossomas encapsulando acido azelaico, bleomicina e 5-fluorouracil para a aplicação na terapia de melanomas

Costa¹,

Moraes²

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Development and validation of a sensitive and selective method using GC/MS-MS for quantification of 5-fluorouracil in hospital wastewater

et al. 2009

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Pollution of the environment by pharmaceuticals is a subject of growing scientific and societal concern. However, few quantitative data have been reported concerning hospital wastewater contamination. Among the different molecules used at hospital, antineoplastic drugs appear to be of special interest, and 5-fluorouracil (5-FU) can be considered as a key compound of this therapeutic class. To monitor this pharmaceutical in hospital wastewater, a highly specific and selective method was developed using gas chromatography tandem mass spectrometry after solid-phase extraction. This sensitive method (limit of quantification = 40 ng L(-1)) was then applied to assess sewage contamination of a middle-size hospital with oncology service located in Paris, France. Native 5-FU was detectable in 12 of the 14 analysed samples. In positive samples, concentration range was measured from 0.09 to 4.0 microg L(-1). Finally, a predicting model for the hospital wastewater concentrations is presented, and results of this model are discussed.

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Simultaneous determination of 5′-deoxy-5-fluorouridine, 5-fluorouracil and 5,6-dihydro-5-fluorouracil in plasma by gas chromatography-mass spectrometry

Cited by 10 publications

References 29 publications

Trace determination of tamoxifen and 5-fluorouracil in hospital and urban wastewaters

Trace determination of tamoxifen and 5-fluorouracil in hospital and urban wastewaters

Preparação e caracterização de lipossomas encapsulando acido azelaico, bleomicina e 5-fluorouracil para a aplicação na terapia de melanomas

Development and validation of a sensitive and selective method using GC/MS-MS for quantification of 5-fluorouracil in hospital wastewater

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