Simultaneous determination of airborne acetaldehyde, acetone, 2-butanone, and cyclohexanone using sampling tubes with 2,4-dinitrophenylhydrazine-coated solid sorbent

Binding, Norbert; Schilder, Karsten; Czeschinski, Peter; Witting, U.

doi:10.1016/s0378-4274(98)00085-x

Cited by 13 publications

(4 citation statements)

References 13 publications

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“…Our results are also consistent with the finding of Kleindienst et al (23) that a discrepancy between DNPH-coated silica gel and C18 cartridges was not associated with breakthrough. As stated earlier, the absence of breakthrough does not necessarily mean ∼100% CE, because DNPH-coated solid sorbents operate on both adsorption and absorption, and the CE of DNPH-coated solid sorbents is largely dependent on the reaction efficiency of the reversible carbonyl-DNPH derivatization reaction (8,21,24,27,29,30). The reversible carbonyl-DNPH derivatization reaction is complex; and is dependent upon parameters such as substrate moisture, substrate pH level, and substrate pH strength.…”

Section: Resultsmentioning

confidence: 98%

“…The absence of breakthrough cannot automatically be translated in to ∼100% CE on the upstream cartridge; because CE is defined as the ratio of the carbonyl concentration determined from the collection media, to the actual (known) concentration. In the case of DNPH-coated solid sorbents, CE is largely dependent on the reaction efficiency of the reversible acid-catalyzed carbonyl-DNPH derivatization reaction (8,21,24,27,29,30). In fact, Grosjean and Grosjean (21) noted that although there was no breakthrough observed by Grosjean and Grosjean (20), the CEs for DNPHcoated solid sorbents sampled in dry air were low.…”

Section: Introductionmentioning

confidence: 99%

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Low Acetaldehyde Collection Efficiencies for 24-Hour Sampling with 2,4-Dinitrophenylhydrazine (DNPH)-Coated Solid Sorbents

Herrington

Fan

Lioy

et al. 2006

Environ. Sci. Technol.

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Airborne aldehyde and ketone (carbonyl) sampling methodologies based on derivatization with 2,4-dinitrophenylhydrazine (DNPH)-coated solid sorbents could unequivocally be considered the "gold" standard. Originally developed in the late 1970s, these methods have been extensively evaluated and developed up to the present day. However, these methods have been inadequately evaluated for the long-term (i.e., 24 h or greater) sampling collection efficiency (CE) of carbonyls other than formaldehyde. The current body of literature fails to demonstrate that DNPH-coated solid sorbent sampling methods have acceptable CEs for the long-term sampling of carbonyls other than formaldehyde. Despite this, such methods are widely used to report the concentrations of multiple carbonyls from long-term sampling, assuming approximately 100% CEs. Laboratory experiments were conducted in this study to evaluate the long-term formaldehyde and acetaldehyde sampling CEs for several commonly used DNPH-coated solid sorbents. Results from sampling known concentrations of formaldehyde and acetaldehyde generated in a dynamic atmosphere generation system demonstrate that the 24-hour formaldehyde sampling CEs ranged from 83 to 133%, confirming the findings made in previous studies. However, the 24-hour acetaldehyde sampling CEs ranged from 1 to 62%. Attempts to increase the acetaldehyde CEs by adding acid to the samples post sampling were unsuccessful. These results indicate that assuming approximately 100% CEs for 24-hour acetaldehyde sampling, as commonly done with DNPH-coated solid sorbent methods, would substantially under estimate acetaldehyde concentrations.

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Section: Resultsmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Low Acetaldehyde Collection Efficiencies for 24-Hour Sampling with 2,4-Dinitrophenylhydrazine (DNPH)-Coated Solid Sorbents

Herrington

Fan

Lioy

et al. 2006

Environ. Sci. Technol.

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“…Szulejko, K-H. Kim /Trends in Analytical Chemistry64 (2015) [29][30][31][32][33][34][35][36][37][38][39][40][41] …”

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confidence: 99%

Derivatization techniques for determination of carbonyls in air

Szulejko

Kim

2015

TrAC Trends in Analytical Chemistry

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“…For formaldehyde and in some cases for acetaldehyde and glutaraldehyde, the preponderance of the laboratories had an overall uncertainty of 30% when using the same method. Binding et al (67) proposed sampling adjustments for regulatory applications with a minimum analytical range from 0.1 to 3 times the exposure limit value and a relative standard deviation below 5%. The adjusted method met all requirements for reliably quantifying the four compounds in workplace air, suggesting that sampling artifacts may play a more limited role at occupationally relevant concentrations.…”

Section: Workplace Methodsmentioning

confidence: 99%

Aldehydes and Acetals

Borchers¹

2012

Patty's Toxicology

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More than 300 aldehydes occur in foods, water, and air. Due to the electrophilicity of the carbonyl carbon, particularly when proximal to a carbon–carbon double bond, aldehydes react with thiols and amines to form protein–protein, DNA–protein, and DNA–DNA cross‐links. Despite their potential for causing cell damage, toxicological and exposure data for a large number of aldehydes are lacking. Inhalation and ingestion studies have demonstrated that a number of aldehydes are irritants and can induce tumors in animal models. Formaldehyde, which is a suspected carcinogen, is the most widely studied of these compounds. The physicochemical properties of saturated aldehydes are summarized. Toxicological and health effects are given.

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Simultaneous determination of airborne acetaldehyde, acetone, 2-butanone, and cyclohexanone using sampling tubes with 2,4-dinitrophenylhydrazine-coated solid sorbent

Cited by 13 publications

References 13 publications

Low Acetaldehyde Collection Efficiencies for 24-Hour Sampling with 2,4-Dinitrophenylhydrazine (DNPH)-Coated Solid Sorbents

Low Acetaldehyde Collection Efficiencies for 24-Hour Sampling with 2,4-Dinitrophenylhydrazine (DNPH)-Coated Solid Sorbents

Derivatization techniques for determination of carbonyls in air

Aldehydes and Acetals

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