Simultaneous determination of alcohols including diols and triols by HPLC with ultraviolet detection based on the formation of a copper(II) complex

Tanaka, Sohei; Dohi, Takumi; Aizawa, Shiro; Kemmei, Tomoko; Terashima, Hiroyuki; Taga, Atsushi; Yamamoto, Atsushi; Kodama, Shuji

doi:10.1002/jssc.201700635

Cited by 10 publications

(4 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A high-performance liquid chromatography (HPLC) method for the determination of propane-1, 2-diol in spirits was proposed by Tanaka et al (2017). In this case, the Cu(II) ions of the mobile phase enable the determination of the substance via an UV-detector (at 250 nm) with a LOD of 0.1 mL/L.…”

Section: Methods Of Analysis In Foodmentioning

confidence: 99%

“…In the literature other methods for manufacturing of propane‐1,2‐diol are reported or proposed, based on a liquid‐phase high pressure reaction (600 atmospheres) of synthetic gas in the presence of a rhodium cluster complex (ASTDR, ), an hydrogenolysis of glycerol by using various catalysts like: copper, nickel or noble metals (Bozga et al., ), highly active copper/magnesia (magnesium oxide) catalysts (Pudi et al., ) or a copper/zinc/magnesia catalyst (Mondal et al., ), chromium oxide, or ruthenium or platinum/tungsten catalysts (Kutz et al., ), via fermentation of deoxy sugars (i.e. rhamnose) or other substrates by using Clostridia, Enterobacteriaceae or yeasts (Tanaka et al., ; Kutz et al. ()). …”

Section: Assessmentmentioning

confidence: 99%

“…• via fermentation of deoxy sugars (i.e. rhamnose) or other substrates by using Clostridia, Enterobacteriaceae or yeasts (Tanaka et al, 2017;Kutz et al (2017)).…”

Section: Manufacturing Processmentioning

confidence: 99%

See 2 more Smart Citations

Re‐evaluation of propane‐1,2‐diol (E 1520) as a food additive

Younes¹,

Aggett²,

Aguilar³

et al. 2018

EFS2

View full text Add to dashboard Cite

The EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) provides a scientific opinion re-evaluating the safety of propane-1,2-diol (E 1520) when used as a food additive. In 1996, the Scientific Committee on Food (SCF) established an acceptable daily intake (ADI) of 25 mg/kg body weight (bw) per day for propane-1,2-diol. Propane-1,2-diol is readily absorbed from the gastrointestinal and is expected to be widely distributed to organs and tissues. The major route of metabolism is oxidation to lactic acid and pyruvic acid. At high concentrations, free propane-1,2-diol is excreted in the urine. No treatment-related effects were observed in subchronic toxicity studies. The available data did not raise concern with respect to genotoxicity. Haematological changes suggestive of an increased red blood cell destruction with a compensatory increased rate of haematopoiesis were observed at the highest dose level (5,000 mg/kg bw per day) in a 2-year study in dogs. No adverse effects were reported in a 2-year chronic study in rats with propane-1,2-diol (up to 2,500 mg/kg bw per day). The SCF used this study to derive the ADI. No adverse effects were observed in the available reproductive and developmental toxicity studies. Propane-1,2-diol (E 1520) is authorised according to Annex III in some food additives, food flavourings, enzymes and nutrients and it is then carried over to the final food. Dietary exposure to E 1520 was assessed based on the use levels and analytical data. The Panel considered that for the food categories for which information was available, the exposure was likely to be overestimated. Considering the toxicity database, the Panel concluded that there was no reason to revise the current ADI of 25 mg/kg bw per day. The Panel also concluded that the mean and the high exposure levels (P95) of the brand-loyal refined exposure scenario did not exceed the ADI in any of the population groups from the use of propane-1,2-diol (E 1520) at the reported use levels and analytical results.

show abstract

Section: Methods Of Analysis In Foodmentioning

confidence: 99%

Section: Assessmentmentioning

confidence: 99%

See 1 more Smart Citation

Re‐evaluation of propane‐1,2‐diol (E 1520) as a food additive

Younes¹,

Aggett²,

Aguilar³

et al. 2018

EFS2

View full text Add to dashboard Cite

show abstract

“…It has been reported that amino acids injected in the HPLC system are readily complexed in the ow of the mobile phase, which contains a Cu(II) ion, and the complexes can be separated by reversed-phase HPLC and detected with a UV detector [18]. In our previous report, we used reversed-phase HPLC with the complexation with Cu(II) ion to determine the organic acids and alcohols [19,20]. Aliphatic carboxylic acids could also be selectively determined by ion chromatography with UV detection based on complexation with a Cu(II) ion [21].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of ethyleneamines by reversed-phase ion-pair chromatography with ultraviolet detection using on-line complexation with copper(II) ion

Yudo,

Kemmei,

Kodama

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

A selective and simple method was developed for the determination of four ethyleneamines (EAs), i.e., ethylenediamine (EDA), diethylenetriamine (DETA), triethylenetetramine (TETA), and tetraethylenepentamine (TEPA), by reversed-phase ion-pair chromatography with ultraviolet detection. The method is based on the on-line complexation of EAs with a Cu(II) ion added to the acetate buffer mobile phase (pH 5.5). The Cu(II) complexes with EAs (Cu(II)-EA complexes) were well separated on a reversed-phased column, using 1-octanesulfonate as an ion-pairing reagent. The concentrations of 1-octanesulfonate and acetonitrile in the mobile phase significantly influenced the retention times of EAs. The high concentration of the Cu(II) ion in the mobile phase resulted in the increase of the baseline noise. Optimum mobile phase conditions were as follows: 0.5 mM CuSO4, 50 mM acetate buffer (pH 5.5), 20 mM 1-octanesulfonate, and 23% (v/v) acetonitrile. Cu(II)-EA complexes could be detected at 243 nm. The limits of quantification of EAs (S/N = 10) were 0.003 mM for EDA, DETA, and TETA and 0.01 mM for TEPA. The calibration curves were linear over three orders of magnitude of EA concentrations with high correlation coefficients (r2 = 1.000). The proposed method was successfully applied to determine EAs in epoxy resin curing agents.

show abstract