Simultaneous determination of antidepressants by non-aqueous capillary electrophoresis-time of flight mass spectrometry

Sasajima, Yasuhide; Lim, Lee Wah; Takeuchi, Toyohide; Suenami, Koichi; Sato, Kiyohito; Takekoshi, Yuji

doi:10.1016/j.chroma.2010.10.003

Cited by 35 publications

(20 citation statements)

References 44 publications

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“…[15] Electroanalytical method with highest sensitivity (LLOQ, 1 ng/ml), which is simultaneous determination of 20 anti-depressants in plasma samples, was carried out by non-aqueous capillary electrophoresis with time of flight mass spectrometry via electrospray ionization. [55] Carbon nanotubes (CNTs) have started a new era for the development of novel electrode materials due to their amazing structural, mechanical, electrical, and physical properties. They have been successfully used as modifiers to obtain very low detection limits.…”

Section: Electroanalytical Methodsmentioning

confidence: 99%

“…[59] Electroanalytical techniques can, in some instances, offer some advantages, among them:(1) Simple sample handling;(2) speed of analysis;(3) high sensitivity; (4) comparable or better accuracy; (5) cheaper instrumentation and lower cost of chemicals used; and (6) limited use of environmentally unfriendly organic solvents. [60] Seven different electroanalytical methods [15,[53][54][55][56][57][58] were found in literature search. Potentiometric titrimetry method for assay of VX raw material is described in BP.…”

Section: Electroanalytical Methodsmentioning

confidence: 99%

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Analytical methods for venlaflaxine hydrochloride and metabolites determinations in different matrices

Shrivastava¹

2012

Syst Rev Pharm

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A B S T R A C TThere may be significant variation in stereoisomers related to distribution, bioavailability, metabolism, and excretion. Venlafaxine is a bicyclic phenylethylamine derivative, a unique antidepressant,which structurally differs from other currently available anti-depressants. Its mechanism of action is believed to be associated with triggering neurotransmitter activity in the CNS. This drug is a racemic mixture of the (−)-R-enantiomer and (+)-S-enantiomer. O-desmethylvenlaflaxine is the major metabolite formed after first pass metabolism with similar potency as parent drug. Two less potent minor metabolites are N-desmethylvenlafaxine and N,O-didesmethylvenlafaxine. Thus, summarization of all of the analytical methods for the determination of venlaflaxine alone, in combination, or in the presence of other metabolites, is summarized. The keywords used for search were "Analytical methods on Venlaflaxine," "Determination of venlaflaxine," "Determination of venlaflaxine and metabolites," and "Venlaflaxine plasma determinations." Eight spectrophotometry, 26 chromatography, and seven electroanalytical methods were found for the determination of venlaflaxine alone, in formulations, biological matrices, and simultaneous determinations with metabolites and other anti-depressants. Short review of pharmacological activity of venlaflaxine and its metabolites are also presented.

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Section: Electroanalytical Methodsmentioning

confidence: 99%

Section: Electroanalytical Methodsmentioning

confidence: 99%

Analytical methods for venlaflaxine hydrochloride and metabolites determinations in different matrices

Shrivastava¹

2012

Syst Rev Pharm

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“…In addition, their misuse, occurring in depressed patients undergoing pharmacological therapy, can be directly or indirectly related to suicide. Sasajima et al developed a NACE-ESI-TOF MS method for the simultaneous determination of 20 antidepressants in plasma samples after SPE [92]. NACE was chosen as a powerful technique for the separation of poorly water soluble compounds, such as most antidepressants.…”

Section: Drugs Of Abusementioning

confidence: 99%

CE-MS in Forensic Sciences with Focus on Forensic Toxicology

Porpiglia

Giacomazzi

Gottardo

et al. 2016

Capillary Electrophoresis-Mass Spectrometry (CE-MS): Principles and Applications

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“…APPI is less affected by non-volatile salts in the CE buffers. Sasijima’s group described the non-aqueous CE with ESI-TOF mass spectrometric method for simultaneous determination of 20 antidepressants in plasma samples [114]. In this method, AA buffer (60 mM) and acetic acid (1 M) in ACN, water and MeOH (100:1:0.5, v/v/v ) were used as background electrolyte.…”

Section: Capillary Electrophoresis-mass Spectro-metrymentioning

confidence: 99%

Recent Advances in Mass Spectrometry for the Identification of Neurochemicals and their Metabolites in Biofluids

Kailasa

2013

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Recently, mass spectrometric related techniques have been widely applied for the identification and quantification of neurochemicals and their metabolites in biofluids. This article presents an overview of mass spectrometric techniques applied in the detection of neurological substances and their metabolites from biological samples. In addition, the advances of chromatographic methods (LC, GC and CE) coupled with mass spectrometric techniques for analysis of neurochemicals in pharmaceutical and biological samples are also discussed.

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Simultaneous determination of antidepressants by non-aqueous capillary electrophoresis-time of flight mass spectrometry

Cited by 35 publications

References 44 publications

Analytical methods for venlaflaxine hydrochloride and metabolites determinations in different matrices

Analytical methods for venlaflaxine hydrochloride and metabolites determinations in different matrices

CE-MS in Forensic Sciences with Focus on Forensic Toxicology

Recent Advances in Mass Spectrometry for the Identification of Neurochemicals and their Metabolites in Biofluids

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