Simultaneous determination of atorvastatin and ezetimibe from combined pharmaceutical products by micellar electrokinetic capillary chromatography

Székely-Szentmiklósi, Blanka; Hancu, Gabriel; Székely-Szentmiklósi, István; Kovács, Béla; Kelemen, Hajnal

doi:10.1590/s2175-97902017000116122

Cited by 5 publications

(3 citation statements)

References 12 publications

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“…Furthermore, the higher molecular weight of ATO and its structural bulkiness obviously explain its elution after ROS although they have quite similar pKa values. Similar elution patterns were reported in MEKC separations of ATO-EZE [ 40 ] and EZE-SIM [ 50 ] binary mixtures.…”

Section: Resultssupporting

confidence: 76%

“…Surveying the literature revealed that different mixtures of EZE with either ATO, ROS or SIM were assayed using various techniques: spectrophotometry [ 15 – 22 ], spectrofluorimetry [ 23 , 24 ], HPLC [ 19 , 25 – 35 ], HPTLC [ 34 – 37 ], UPLC [ 38 ], MEKC [ 39 , 40 ] and CE [ 41 ]. However, there is no reported capillary electrophoresis (CE)-based method for the synchronized determination of the 3 statins together with EZE.…”

Section: Introductionmentioning

confidence: 99%

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Development of a sustainable multianalyte MEKC method for quantitation of the antihyperlipidemic drugs ezetimibe together with three statins. Greenness and whiteness appraisal studies

Elbordiny,

Elonsy,

Daabees

et al. 2023

BMC Chemistry

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Implementing powerful and sustainable research that complies with green analytical chemistry (GAC) and white analytical chemistry (WAC) fundamentals can downsize the environmental compliance costs and fruitfully affects practical and economic issues. Within this framework, rapid and white analytical micellar electrokinetic capillary chromatography (MEKC) methodology was developed for the synchronized estimation of the antihyperlipidemic drugs Ezetimibe (EZE), Atorvastatin (ATO), Rosuvastatin (ROS) and Simvastatin (SIM). The technique was established using fused silica capillary (50 cm, 50 µm id) and the background electrolyte was 0.025 M borate buffer pH 9.2 containing 0.025 M sodium dodecyl sulfate (SDS) and 10% v/v acetonitrile as the organic modifier. Diode array detector was adjusted at 243 nm for ATO and ROS and 237 nm for EZE and SIM. Separation was accomplished within 10 min with migration times of 4.12, 5.42, 8.23 and 8.74 min for ROS, ATO, EZE and SIM respectively. The 4 drugs were quantitated in the concentration range of 10–100 μg/mL and the correlation coefficients were not less than 0.9993. The high sensitivity was illustrated by values of the detection and quantitation limits. The limits of detection for ROS, ATO, EZE and SIM were 0.52, 0.75, 0.42 and 0.64 μg/mL, respectively, whereas, the limits of quantitation values were 1.73, 2.50, 1.40 and 2.13 μg/mL for the studied drugs, respectively. In addition to validation, as reported by the ICH guidelines, greenness and whiteness assessment using the novel AGREE calculator and the holistic functionality model RGB12 were performed. The results proved the efficiency and whiteness of the suggested technique to be routinely implemented in quality control laboratories for the assay of the four drugs and the binary mixtures of EZE with either ATO, ROS or SIM in fixed-dose combined tablets.

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Section: Resultssupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Development of a sustainable multianalyte MEKC method for quantitation of the antihyperlipidemic drugs ezetimibe together with three statins. Greenness and whiteness appraisal studies

Elbordiny,

Elonsy,

Daabees

et al. 2023

BMC Chemistry

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show abstract

“…Mérési paraméterek: hőmérséklet 20°C, alkalmazott feszültség +20 kV, injektálási nyomás 50 mbar/1 sec. A detektálás UV fényben 230 nm hullámhossznál történt [17].…”

Section: A Mikroszálak Hatóanyagtartalmának Meghatározásaunclassified

Solubility enhancement of atorvastatin by embedding in micro sized carrier

Rédai

Mónika

Székely-Szentmiklósi

et al. 2019

Bulletin of Medical Sciences

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The aim of this experimental work was the enhancement of water solubility of the lipid lowering atorvastatin, by embedding it in polymer based micro sized fibers obtained by electrospinning. We prepared a polyvinylpyrrolidone (Kollidon 90F®) dispersion and added the active substance. By setting the experimental parameters we obtained four different microfibers containing atorvastatin, and one without the drug. The pH, viscosity and conductivity of the dispersions have been measured. The drug content and dissolution of atorvastatin had been studied by capillary electrophoresis. The size and thermal behavior of the fibers was determined. The parameters of the microfibers are influenced by the experimental parameters of electrospinning. The micro-method for dissolution showed a twofold solubility enhancement.

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Design of trio-colored validated HPLC method for synchronized multianalyte quantitation of four top selling antihyperlipidemic drugs in different fixed-dose combined tablets

Elbordiny,

Elonsy,

Daabees

et al. 2024

Green Analytical Chemistry

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Simultaneous determination of atorvastatin and ezetimibe from combined pharmaceutical products by micellar electrokinetic capillary chromatography

Cited by 5 publications

References 12 publications

Development of a sustainable multianalyte MEKC method for quantitation of the antihyperlipidemic drugs ezetimibe together with three statins. Greenness and whiteness appraisal studies

Development of a sustainable multianalyte MEKC method for quantitation of the antihyperlipidemic drugs ezetimibe together with three statins. Greenness and whiteness appraisal studies

Solubility enhancement of atorvastatin by embedding in micro sized carrier

Design of trio-colored validated HPLC method for synchronized multianalyte quantitation of four top selling antihyperlipidemic drugs in different fixed-dose combined tablets

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