Simultaneous Determination of Baicalin, Baicalein, Wogonin, Oxysophocarpine, Oxymatrine and Matrine in the Chinese Herbal Preparation of Sanwu-Huangqin-Tang by Ion-Paired HPLC

Zhang, Lei; Xu, Liang; Tan, Xiaojie; Liao, Qiongfeng; Guo, Wei; Chen, Xiaohui; Bi, Kaishun

doi:10.1365/s10337-007-0260-4

Cited by 14 publications

(5 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Radix sophorae flavescentis (Ku shen) was used to alleviate toxicity, killed parasites and induced diuresis according to Chinese medicinal theory [200]. Many traditional formulas contain Radix sophorae flavescentis , for example, “Xiaofeng San” was prescribed for treating cutaneous disorders [201], and “Sanwu Huangqin Tang” has long been used for post-partum fevers arising from reproductive organ infections during childbirth [202]. These therapeutic effects suggest the immunomodulatory and anti-inflammatory function of Radix sophorae flavescentis may be attributed to the maintenance of systemic homeostasis by clearing off metabolic wastes through autophagy.…”

Section: Role Of Manipulating Autophagy In the Pathogenesis Of Hummentioning

confidence: 99%

New Potential Pharmacological Functions of Chinese Herbal Medicines via Regulation of Autophagy

Law

Mok

et al. 2016

Molecules

View full text Add to dashboard Cite

Autophagy is a universal catabolic cellular process for quality control of cytoplasm and maintenance of cellular homeostasis upon nutrient deprivation and environmental stimulus. It involves the lysosomal degradation of cellular components such as misfolded proteins or damaged organelles. Defects in autophagy are implicated in the pathogenesis of diseases including cancers, myopathy, neurodegenerations, infections and cardiovascular diseases. In the recent decade, traditional drugs with new clinical applications are not only commonly found in Western medicines, but also highlighted in Chinese herbal medicines (CHM). For instance, pharmacological studies have revealed that active components or fractions from Chaihu (Radix bupleuri), Hu Zhang (Rhizoma polygoni cuspidati), Donglingcao (Rabdosia rubesens), Hou po (Cortex magnoliae officinalis) and Chuan xiong (Rhizoma chuanxiong) modulate cancers, neurodegeneration and cardiovascular disease via autophagy. These findings shed light on the potential new applications and formulation of CHM decoctions via regulation of autophagy. This article reviews the roles of autophagy in the pharmacological actions of CHM and discusses their new potential clinical applications in various human diseases.

show abstract

Section: Role Of Manipulating Autophagy In the Pathogenesis Of Hummentioning

confidence: 99%

New Potential Pharmacological Functions of Chinese Herbal Medicines via Regulation of Autophagy

Law

Mok

et al. 2016

Molecules

View full text Add to dashboard Cite

show abstract

“…Various analytical tools such as capillary electrophoresis, ion-paired high-performance liquid chromatography (HPLC), HPLC with electrochemical detection and liquid chromatography-mass spectrometry have been developed for the analysis of active components in Scutellariae Radix extract, as well as in matrixes such as plasma and urine (Wakui et al, 1992;Wu, Yan, Li, Liu, & Liu, 2004;Zhang et al, 2006Zhang et al, , 2007. However, HPLC with UV detection is the most widely used method for the analysis of herbal medicines, and there are several published methods for the analysis of Scutellariae Radix (Gao et al, 2008;Kova´cs, Kuzovkina, Szo 00 ke, & Kursinszki, 2004;Li et al, 2009;Sheu & Chen, 1995;Zuo, Zhou, & Liu, 2001).…”

Section: Introductionmentioning

confidence: 99%

A simple isocratic HPLC method for the simultaneous determination of bioactive components of Scutellariae Radix extract

Islam

Chung

Kim

et al. 2012

Natural Product Research

View full text Add to dashboard Cite

Scutellariae Radix, the dried root of Scutellaria baicalensis Georgi, has been widely used in Asian countries for the treatment of dermatitis, diarrhoea, inflammatory disease and hepatic disease. A simple, sensitive and precise reversed-phase liquid chromatographic method with isocratic elution was developed to simultaneously determine four bioactive compounds in Scutellariae Radix: baicalein, baicalin, wogonin and wogonoside. Chromatographic analysis was performed on a YMC Pack Pro C(8) column (150 × 4.6 mm(2), 3 µm), with a mobile phase of 0.1% formic acid : acetonitrile (70 : 30, v/v) at a flow rate of 1.0 mL min(-1), and UV detection at 280 nm. Linear behaviour was observed over the investigated concentration range (0.25-10 µg mL(-1)) for all analytes, with a correlation coefficient of >0.997. The intra- and inter-day precisions were <8.07%, and accuracies were 92.3-102.9%. This method was successfully applied for the analysis of marker compounds for the quality control of Scutellariae Radix extract.

show abstract

“…As far as SHT is concerned, our previous study has revealed that the content of target compounds in SHT varied greatly compared with those in crude drugs. 23 The phenomenon is because the extraction efficiency could be affected, and the interchange of compounds could occur when Radix scutellariae, Radix sophorae avescentis and Rehmanniae Rhizomac were codecocted together. Thus, it is difficult to guarantee the equivalent administration dose for the comparative study.…”

Section: Our Thought About the Component Compatibility Of Shtmentioning

confidence: 99%

Comparative pharmacokinetic and tissue distribution study of baicalin, baicalein, wogonoside, wogonin and oroxylin-A after oral administration of Component compatibility of SHT and total flavonoids fractions of Radix scutellariae to rats

Feng

Yao

et al. 2014

Anal. Methods

Self Cite

View full text Add to dashboard Cite

show abstract

Simultaneous Determination of Baicalin, Baicalein, Wogonin, Oxysophocarpine, Oxymatrine and Matrine in the Chinese Herbal Preparation of Sanwu-Huangqin-Tang by Ion-Paired HPLC

Cited by 14 publications

References 20 publications

New Potential Pharmacological Functions of Chinese Herbal Medicines via Regulation of Autophagy

New Potential Pharmacological Functions of Chinese Herbal Medicines via Regulation of Autophagy

A simple isocratic HPLC method for the simultaneous determination of bioactive components of Scutellariae Radix extract

Comparative pharmacokinetic and tissue distribution study of baicalin, baicalein, wogonoside, wogonin and oroxylin-A after oral administration of Component compatibility of SHT and total flavonoids fractions of Radix scutellariae to rats

Contact Info

Product

Resources

About