Simultaneous determination of benazepril hydrochloride and hydrochlorothiazide by micro-bore liquid chromatography

Panderi, Irene; Parissi-Poulou, M.

doi:10.1016/s0731-7085(99)00195-8

Cited by 45 publications

(25 citation statements)

References 17 publications

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“…EIS data were obtained at ac frequency varying between 0.1 Hz and 100 kHz. As shown in Figure 2 A 6 ] decreases greatly, and the charge transfer rate is enhanced in case of using ILCMCPE/SDS.…”

Section: Electrochemical Impedance Spectroscopy (Eis) Studiesmentioning

confidence: 93%

“…The data analysis software was provided with the instrument and applied non-linear least square fitting with Levenberg-Marquardt algorithm. The parameters in electrochemical impedance experiment were as follows: different potential values 0.333 V, 0.360 V, 0.317 V and 0.287 V at frequency range of 0.1-100000 Hz with amplitude of 5 mV, were applied on bare CPE, ILMCPE1/SDS, ILMCPE2/SDS and ILCMCPE/SDS which were tested in 5.0 10 À3 M K 4 [Fe(CN) 6 ] dissolved in 0.1 M KCl.…”

Section: Impedance Spectroscopy Measurementsmentioning

confidence: 99%

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Electroanalysis of Benazepril Hydrochloride Antihypertensive Drug Using an Ionic Liquid Crystal Modified Carbon Paste Electrode

2015

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Electroanalysis of benazepril HCl was successful using a carbon paste electrode modified with an ionic liquid crystal (1‐butyl‐1‐methylpiperidinium hexafluorophosphate) in presence of sodium dodecyl sulfate. The electrode performance was compared to ionic liquids (1‐n‐hexyl‐3‐methyl imidazolium tetrafluoroborate and 1‐butyl‐4‐methyl pyridinium tetrafluoroborate). Electrochemical determination of benazepril HCl was in the linear dynamic range of 8.89×10−7 to 1.77×10−5 mol L−1 (correlation coefficient 0.999) and LOD 7.17×10−9 mol L−1. benazepril HCl was determined using this sensor in presence of urine metabolites such as uric acid, ascorbic acid. Binary mixtures of dopamine/benazepril and amlodipine/benazepril were also determined successfully.

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Section: Electrochemical Impedance Spectroscopy (Eis) Studiesmentioning

confidence: 93%

Section: Impedance Spectroscopy Measurementsmentioning

confidence: 99%

Electroanalysis of Benazepril Hydrochloride Antihypertensive Drug Using an Ionic Liquid Crystal Modified Carbon Paste Electrode

2015

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“…RP-HPLC, HPTLC, and UV-Visible spectrophotometric methods has been reported for estimation of HCT with another drug combination instead of BEN in bulk and pharmaceutical dosage form [6][7][8][9][10][11][12][13][14][15]. LC and HPTLC method has been reported for simultaneous estimation of BEN and HCT in bulk and pharmaceutical dosage form [16,17]. In the proposed study, attempt has been made to develop stability indicating liquid chromatographic method for the estimation of BEN and HCT in pharmaceutical dosage form as per ICH guide lines [18,19].…”

Section: Benazepril Hyrochloride (Ben) Is Chemically 3-[[1-(ethoxycarmentioning

confidence: 99%

Stability Indicating LC Method for the Estimation of Benazepril HCl and Hydrochlorthiazide in Pharmaceutical Dosage Form

LB¹

2014

J Chromat Separation Techniq

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A rapid, specific and sensitive reverse phase high performance liquid chromatographic method has been developed and validated for analysis of benazepril hydrochloride and hydrochlorothiazide in both bulk and pharmaceutical dosage form. A sunfire C-18, 250×4.6 mm i.d. and 5 µm particle size column with mobile phase containing water: methanol (55:45, v/v, pH 7). The flow rate was 1.0 mL min -1 and effluents were monitored at 233 nm. The retention time of benazepril hydrochloride and Hydrochlorthiazide was 9.19 min and 3.10 min respectively. Benazepril hydrochloride and hydrochlorthiazide was subjected to acid and alkali hydrolysis, chemical oxidation, wet hydrolysis, dry heat degradation and sun light degradation. The degraded product peaks were well resolved from the pure drug peak with significant difference in their retention time values. Stressed samples were assayed using developed LC method. The proposed method was validated with respect to linearity, accuracy, precision and robustness. The method was successfully applied to the estimation of benazepril hydrochloride and hydrochlorthiazide in tablet dosage forms.

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“…It suggests that the degradation products, which were formed under variety of conditions, should be identified and degradation pathways are to be established [5] . The literature survey reveals that several methods [6][7][8][9][10][11][12][13] were reported for the determination of IRB and hydrochlorothiazide. The methods [14][15][16][17] for IRB in combination with other drugs in plasma and serum were done by high-performance liquid chromatography (HPLC) and the few analytical methods have been reported on stability-indicating assay by HPLC method [18,19] .…”

mentioning

confidence: 99%

Rapid Stability-indicating RRLC Method for Simultaneous Estimation of Irbesartan and its Related Impurities

Rao¹,

Rao²

2016

ijps

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Tirumala Rao, et al.: Stability-indicating RRLC Method for Irbesartan A green, novel gradient stability-indicating reverse phase rapid resolution liquid chromatographic method was developed and validated for simultaneous estimation of irbesartan and along with six related impurities in active pharmaceutical ingredient samples. The chromatographic separation was achieved on Kromasil C8 (3.5 µm, 150×4.6 mm) short column with 0.1% v/v ortho-phosphoric acid and acetonitrile as mobile phase using gradient elution. The developed method showed good resolution between irbesartan and its six related impurities and were eluted within 15 min. run time of LC chromatogram. Regression analyses indicate correlation coefficient value greater than 0.999 for irbesartan and its six related impurities. The limit of detection for irbesartan and the known related impurities were observed at a level below 0.004% (0.019 µg/ml and the method is showing better recoveries for irbesartan (99.6-100.7%) and also for its six known impurities (88.5-98.9%). The test solution and related substances were found to be stable in the diluents for 24 h. The developed stability-indicating method is found to be rapid, accurate, precise, linear, specific, sensitive, rugged, robust, and stability-indicating. The application of developed method was also verified by an assay of irbesartan and related substances in commercial bulk drug samples and more essentially, the method is economic and environment friendly than the other published methods. Key words: Irbesartan RRLC, stability-indicating, related substances, validationIrbesartan (IRB) is chemically described as 2-butyl-Its empirical formula is C 25 H 28 N 6 O, and molecular weight is 428.5 amu. IRB is an active non-peptide specific angiotensin II receptor antagonist (AT1 subtype) used as antihypertensive agent. Hypertension is the most prevalent cardiovascular disease in the developed as well as developing countries, affecting as many as one quarter of the adult population.Furthermore, hypertension is an independent risk factor for cardiovascular diseases and associated with an increased incidence of stroke and coronary heart disease. Angiotensin II antagonists are major drugs used in hypertension management in the recent decade. Their lower side effect profile and specificity in the action provided a good condition for patient compliance as well as effectiveness. Therefore, these drugs are used as first line treatment for hypertension [1][2][3][4] . Stability testing of new drug substances and drug products requires a stress testing, which should be carried out to elucidate the inherent stability characteristics of the active substance. It suggests that the degradation products, which were formed under variety of conditions, should be identified and degradation pathways are to be established [5] . The literature survey reveals that several methods [6][7][8][9][10][11][12][13] were reported for the determination of IRB and hydrochlorothiazide. The methods [14][15][16][17] for IRB in combination with ot...

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Simultaneous determination of benazepril hydrochloride and hydrochlorothiazide by micro-bore liquid chromatography

Cited by 45 publications

References 17 publications

Electroanalysis of Benazepril Hydrochloride Antihypertensive Drug Using an Ionic Liquid Crystal Modified Carbon Paste Electrode

Electroanalysis of Benazepril Hydrochloride Antihypertensive Drug Using an Ionic Liquid Crystal Modified Carbon Paste Electrode

Stability Indicating LC Method for the Estimation of Benazepril HCl and Hydrochlorthiazide in Pharmaceutical Dosage Form

Rapid Stability-indicating RRLC Method for Simultaneous Estimation of Irbesartan and its Related Impurities

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